Africans turning into violent Zombies

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The Grim Squeaker
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Africans turning into violent Zombies

Post by The Grim Squeaker »

Baffling Illness Strikes Africa, Turns Children Into Violent "Zombies"
World Health Organization is on high alert about new Ugandan outbreak, cause is not fully known

It's called the "nodding disease" and it's a baffling illness that has struck thousands of children in northern Uganda. The illness brings on seizures, violent behavior, personality changes, and a host of other unusual symptoms.

I. Violent and Mindless: Child Victims Have no Cure, no Future

Grace Lagat, a northern Uganda native, is mother of two children -- Pauline Oto and Thomas -- both of whom are victims of the disease. For their safety, when she leaves the house, she now ties them up, using fabric like handcuffs. She recalls, "When I am going to the garden, I tie them with cloth. If I don't tie them I come back and find that they have disappeared."

Reportedly the children gnaw at their fabric restraints, like a rabid animals -- or "zombies" of popular fiction -- in an attempt to escape.

The effort to restrain the children is not unwarranted. In one of the most bizarre symptoms of this tragic illness, children with the disease are reportedly setting fire to buildings in their communities. Coupled with the aimless wandering this disease provokes in victims, this is a deadly combination. More than 200 people have been killed in fires believed to be set by the zombified children.

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The disease leaves child victims in an often-violent "zombiefied" state. [Image Source: CNN]

The disease is not new. It popped up in the 1960s in Sudan. From there it slowly spread to Libya and Tanzania.

The Uganda infections, though, are a new outbreak -- a troubling sign. The jump into a new region could be pure coincidence, or it could indicate the disease has become more virulent or found a new transmissions vector.


Uganda is located in central Africa [Image Source: U of Tex., Modifications: Jason Mick]

Infected children typically have regular seizures, which are proceeded by a repetitive nodding of the head. This characteristic symptom has given rise to the unofficial title for the malady.

II. World Medical Organizations Racing for a Cure

The Center for Disease Control (CDC) and World Health Organization (WHO) have been tracking the spread of this frightening ailment. Dr. Joaquin Saweka says the scene in Uganda is horrific, stating, "It was quite desperate, I can tell you. Imagine being surrounded by 26 children and 12 of them showing signs of this. The attitude was to quickly find a solution to the problem."

Yet the WHO and CDC are not fully sure what is causing the illness, which cripples children and turns them into mindless, violence-prone zombies. The best clue they have is that most of the cases occur in regions inhabited by "Black flies", which carry the parasitic worm Onchocerca Volvulus. That worm is responsible for another dangerous disease dubbed "river blindness", the world's second leading cause of infectious blindness.


The illness may have something to do with Black flies (left, center) and their parasitic worm (right). [Image Source: WHO (left), Wikimedia Commons (center), Human Healths (right)]

However 7 percent of infected children live in regions not inhabited by the Black fly, so a link is speculative at best.

Children with the disease also frequently exhibit vitamin B6 deficiency, leading medical experts to believe that the disease may be nutrition related. However, infections by microbes, parasites, fungi, or even fungi/microbes carried by a parasitic host, can all lead to nutritional deficiencies.

Dr. Scott Dowell, director of global disease detection and emergency response at CDC, says the race is on to determine the cause and a cure. He states, "At first we cast the net wide. We ruled out three dozen potential causes and we are working on a handful of probabilities. We know from past experience an unknown disease could end up having more global implications."

In the current cases children as old as 19 have been found to be stricken, with the majority of the worst symptoms being spread over the 3-11 age range.

One mystery surrounding the disease is the seizures themselves. While typically seizures are either randomly occurring or follow some singular cue/pattern, the nodding disease seems to have multiple triggers, including eating new foods, changing weather, and other changes.

Seizure often leave the children soiled with urine and drooling. Local nurses are afraid to touch the infected. States local nurse Elupe Petua, "I feel, because I don't know what causes it, I don't even know how it transmits, when I touch them I feel that I can also get the infection because I don't know what causes it."

III. Medication is Ineffective

Anti-epileptic medication slows the onset of symptoms, but is unable to stop the progression of the disease. The seizures eventually leave many children unable to walk, only able to drag their bodies along the ground as flies tried to attack them.


The current treatment approach of anti-epileptics has done little to halt the illness.
[Image Souce: CNN]

The government of Uganda has come under criticism for not being vocal enough in addressing the tragedy and demanding foreign aid/research expertise. Local politicians have taken to transporting victims from affected villages by bus to city hospitals in order to force the issue into the eyes of the more affluent city-dwellers.

The issue is yet another woe for a nation in which the impoverished majority was terrorized for years by warlord Jospeph Kony's militia, dubbed the "Lord's Resistance Army."

Mr. Kony is currently wanted by the International Criminal Court on multiple counts of violent war crimes, including rape and murder. These offenses are punishable by death, if he is ever brought to trial.

IV. What if the "Nodding Disease" Found a Way to Reach the U.S.?

Dr. Saweka says that for all the hand-waving by the government about using better anti-epileptics and offering more funding, he appreciates and shares in the villagers frustration. He states, "People complain that it looks like the lives in developing countries have less value than the lives in the western countries. When you know the root cause, you address the cure. Now you are just relieving the symptoms. We don't expect to cure anybody."


Ugandans, grief stricken, feel somewhat abandoned by the government and the wealthy developed "First World". [Image Source: CNN]

While the "First World" may not be focused on -- or even aware of -- the zombification that is leaving children in these African nations violent, crippled shells of their former selves -- tied like dogs -- it is an issue that must be addressed. After all, viruses, bacteria, parasites thanks to the wonders of evolution can mutate and adapt to new environments and new transmission vectors.

Thus this zombie virus may seem like a foreign issue to regions like the U.S. and EU who are struggling with their own financial crisises. But if the illness finds a way to broaden its spread, this "zombie" outbreak could cripple the globe.
Source: CNN

Baffling Illness Strikes Africa, Turns Children Into Violent "Zombies"
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You can't make this sort of thing up. (And wasn't this the plot of RE4, down to the cause being a weirdass parasite?)
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Re: Africans turning into violent Zombies

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It's not as weird as one might think, there's plenty of parasites that induce behavioral changes in the hosts in order to further their own reproductive cycle.
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Re: Africans turning into violent Zombies

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It could also be a product of a parasite plus a viral disease or other combinations cooking the brain. The edges of the Congo basin are home to a great many diseases we don't understand very well.
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Re: Africans turning into violent Zombies

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Horrible story, but, can we please stop referring to "Africans" instead of "Ugandans", thank you very much.
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Re: Africans turning into violent Zombies

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Chirios wrote:Horrible story, but, can we please stop referring to "Africans" instead of "Ugandans", thank you very much.
The Sudanese, Libyans and Tanzanians are not Ugandans.
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Re: Africans turning into violent Zombies

Post by Ziggy Stardust »

PeZook wrote:It's not as weird as one might think, there's plenty of parasites that induce behavioral changes in the hosts in order to further their own reproductive cycle.
Hell, even a bad fever can induce behavioral changes, without need of the direct interaction with a parasite.

I am curious whether this disease is actually "new", or not, or if it is something that has existed in remote corners of Africa for a long time, but for a variety of reasons is only now prevalent enough to attract Western attention. Both "river blindness" and sleeping sickness, for example, like were effecting people for centuries before formal recognition/description by Europeans. This could be just some especially rare infection, or one that only exhibits these particular symptoms under the right conditions.
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Re: Africans turning into violent Zombies

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There's a reason why Africa is the deadliest continent for humans in terms of parasites: We evolved there. So all the really bad shit on that continent has been coexisting with humans for as long as we've been humans and has been in an evolutionary arms race with us since before we were humans.

On all the other continents, the parasites have had much less time to get where the African parasites are. So while there are really goddamn disgusting and horrific things in e.g. South America, they are not as common or as varied as the things in Africa.

The thing with outbreaks like this is that with the vastly increased travel and contact between people, they have an opportunity to become more common and spread wider. It is also a sign of the relatively civilized times we live in that the situation is being treated the way it is. In the bad old days, an outbreak like this could well have resulted in neighboring tribes deciding to cleanse the afflicted ones with machete and fire to eliminate the threat.
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Re: Africans turning into violent Zombies

Post by Simon_Jester »

The frightening thing is... In the bad old days, that was about the closest thing the neighboring tribes had to a public health measure- how else would you go about blocking or delaying the spread of a chronic infectious disease with pre-industrial technology?

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Re: Africans turning into violent Zombies

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The Grim Squeaker wrote: Baffling Illness Strikes Africa, Turns Children Into Violent "Zombies"
:0
You can't make this sort of thing up. (And wasn't this the plot of RE4, down to the cause being a weirdass parasite?)
Resident Evil 5, actually.

And Holy shit, how does real life keep trumping fiction anyway?

Waitaminute... aren't the government of Uganda the guys who are trying to make being gay a capital offense? And they're ignoring this? "Nevermind the sick children setting your homes on fire! The gays are the real threat!"
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Re: Africans turning into violent Zombies

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SAMAS wrote: Waitaminute... aren't the government of Uganda the guys who are trying to make being gay a capital offense? And they're ignoring this? "Nevermind the sick children setting your homes on fire! The gays are the real threat!"
Yes they wanted to increase the penalty for being gay from 14 years to either life in prison, or death in the case of people who are repeat offenders and under various other 'aggravating' conditions. The Parliament refused to vote on it in the end, but its still on the table.
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Re: Africans turning into violent Zombies

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SAMAS wrote:And Holy shit, how does real life keep trumping fiction anyway?
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Re: Africans turning into violent Zombies

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Broomstick wrote:
SAMAS wrote:And Holy shit, how does real life keep trumping fiction anyway?
"My own suspicion is that the Universe is not only queerer than we suppose, but queerer than we can suppose." - J.B.S. Haldane.

Life on Earth has had 4,000,000,000+ years to come up with stuff - did you really think puny humans would do better in a mere 100,000 or so?
No, not really.

Any of the biology guys going to weigh in here? Us Maths and Logic guys are just going to have to sit out for the moment.
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Re: Africans turning into violent Zombies

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Chirios wrote:Any of the biology guys going to weigh in here? Us Maths and Logic guys are just going to have to sit out for the moment.
Well, some elements of the CNN article are wildly exaggerated or hideously inaccurate, but that's no surprise.

Honestly, not a lot if known about this disease, so it's hard to really comment on it. The article notes that this tends to occur in areas where river blindness is also prevalent, which has also been linked to epilepsy, stunted growth, and mental retardation. However, not all the victims of nodding syndrome are hosts to the parasite (though a disproportionate number are), and river blindness is also prevalent in areas with no evidence of the nodding disease existing. Also, it seems from a little searching that the first cases of this particular disease were found in the mountains regions of the Sudan, while river blindness seems to primarily effect flatter, tropical locations (prevalence map; notice the grey areas where the mountains of central Africa can be found).

It is a bit of a mystery, for sure, though it seems apparent there is at least SOME relationship to the river blindness parasites, though maybe not a DIRECT one.

To be fair, though, this isn't even the weirdest mental effects that parasites can have on people. There is some evidence that an infection of the protozoan Toxoplasma gondii can cause severe psychological problems, such as depression, schizophrenia, and alterations in dopamine production, a neurotransmitter involved in mood, anxiety, sociability, attention, motivation, sleep patterns, etc. etc.
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Re: Africans turning into violent Zombies

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How do you get yourself tested for Toxoplasmosis anyway? I've owned semi-feral cats and played in the dirt my whole life.
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Re: Africans turning into violent Zombies

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Ziggy Stardust wrote:However, not all the victims of nodding syndrome are hosts to the parasite (though a disproportionate number are), and river blindness is also prevalent in areas with no evidence of the nodding disease existing.
Given just how many human parasites exist in Africa as a whole, the overlap with river blindness just might be purely coincidental. There is probably a correlation with other varieties of parasites, too, but that does not automatically prove causation.
cosmicalstorm wrote:How do you get yourself tested for Toxoplasmosis anyway? I've owned semi-feral cats and played in the dirt my whole life.
Blood test utilizing PCR, but it's possible for the parasite to be so dormant as to be undetectable. Something like half the human race has the parasite, and in the US the infection rate is something likst 10% overall. In other words, it's pretty common. Fortunatley, most human hosts seemed unaffected, or so minimally as to make no difference. The danger is if your immune system becomes weakened (such as with HIV infection, or cancer treatment) or if you're one of the rare individuals with unusual susceptibility to it.
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Re: Africans turning into violent Zombies

Post by Ziggy Stardust »

Broomstick wrote: Given just how many human parasites exist in Africa as a whole, the overlap with river blindness just might be purely coincidental. There is probably a correlation with other varieties of parasites, too, but that does not automatically prove causation.
Yes, but the correlation is a bit stronger than simple prevalence overlap. Some of the symptoms associated with nodding disease have also been associated with cases of river blindness, as a couple of the sources I linked to indicate. You are right, this does not prove causation, but that is a much stronger correlation than simply both happening in a similar geographic region. Furthermore, somewhere between 70%-90% of the victims of nodding disease tested were also host to the river blindness parasite (or showed antibodies related to it), which is FAR above the normal levels in the population. So while one probably does not cause the other, there is certainly a pretty strong relationship of some sort.

Broomstick wrote: Blood test utilizing PCR, but it's possible for the parasite to be so dormant as to be undetectable. Something like half the human race has the parasite, and in the US the infection rate is something likst 10% overall. In other words, it's pretty common. Fortunatley, most human hosts seemed unaffected, or so minimally as to make no difference. The danger is if your immune system becomes weakened (such as with HIV infection, or cancer treatment) or if you're one of the rare individuals with unusual susceptibility to it.
This. The chances of it effecting you are pretty minimal. Unless you are really unlucky, any condition that weakens your immune system is more pressing than the chemical imbalances Toxoplasmosis have been linked to.
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Re: Africans turning into violent Zombies

Post by Alyrium Denryle »

Well, there are a few possibilities here. It is biological speculation time.

Possibility 1) New parasite, possibly with black flies as a facultative transmission vector. This could be a parasite that has previously gone undiscovered, or just recently jumped hosts to people (or to a new vector that permits them to more easily infect people. It may have jumped hosts from some other dipteran to black flies, for example, and that seven percent represent kids who contracted it from the previous host vector). This would also explain the prevalence of river blindness, as the two infections could be co-occurring.

Possibility 2) Old parasite, new symptom. It is Africa. It is not as if it does not have plenty of parasites. This would not explain the river blindness prevalence however, unless this parasite has a few different hosts, one of which is the black fly.

Possibility 3) This could be a side effect of pesticides used to control said black flies. Pesticides are NOT really tested very well for long-term exposure effects, or for effects across generations (a child born to a parent--or even grandparent-- exposed to some pesticides can be harmed because of damage done to germ line cells and DNA damage). Of course, I have an axe to grind with pesticide testing standards....
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