The first article I was involved in got published. Yay!
(I'm a minor co-contributor, but it still counts ^_^. Now I await the first round of peer reviews on my real "baby" (an article where i'm the first author), but that's still in the hands of the fickle gods of acceptance and editing).
http://www.mdpi.com/2072-6651/5/7/1314
"Short Toxin-like Proteins Attack the Defense Line of Innate Immunity"
ToLIPS are pretty dang interesting BTW .
It's an open access journal for anyone who wants to read it.Short Toxin-like Proteins Attack the Defense Line of Innate Immunity
Yitshak Tirosh, Dan Ofer, Tsiona Eliyahu and Michal Linial
Department of Biological Chemistry, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Toxins 2013, 5(7), 1314-1331; doi:10.3390/toxins5071314
Published: 23 July 2013
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
Abstract:
ClanTox (classifier of animal toxins) was developed for identifying toxin-like candidates from complete proteomes. Searching mammalian proteomes for short toxin-like proteins (coined TOLIPs) revealed a number of overlooked secreted short proteins with an abundance of cysteines throughout their sequences.
We applied bioinformatics and data-mining methods to infer the function of several top predicted candidates.
We focused on cysteine-rich peptides that adopt the fold of the three-finger proteins (TFPs). We identified a cluster of duplicated genes that share a structural similarity with elapid neurotoxins, such as α-bungarotoxin. In the murine proteome, there are about 60 such proteins that belong to the Ly6/uPAR family. These proteins are secreted or anchored to the cell membrane. Ly6/uPAR proteins are associated with a rich repertoire of functions, including binding to receptors and adhesion. Ly6/uPAR proteins modulate cell signaling in the context of brain functions and cells of the innate immune system. We postulate that TOLIPs, as modulators of cell signaling, may be associated with pathologies and cellular imbalance. We show that proteins of the Ly6/uPAR family are associated with cancer diagnosis and malfunction of the immune system.
http://www.mdpi.com/2072-6651/5/7/1314/pdf