Starglider wrote: He3 is rare on earth, but it's a lot more common than tritium or even lithium to breed tritium with in the universe in general, so He3 fusion wins for sci-fi concepts
The concentration of helium-3 in Jupiter and the other gas giants is very low, like parts per billion. In general, helium-3 is not so
much as a millionth of total helium. Helium-3 fusion might be developed someday, perhaps, though more difficult than deuterium-tritium fusion to get working at all, but it doesn't win on availability of fuel.
It could be unfortunate to choose such a rare isotope when otherwise space solar power or thermonuclear power would not tend to run into troubles like nations squabbling over who gets to skim off the trace helium-3 on the moon. The amount is usually estimated as on the order of a single million tons, while the moon's surface area is millions of square kilometers, with past solar wind deposition of helium-3 presumably spreading it over the area, so many square kilometers of lunar surface have to be processed per small number of tons of helium-3. For nuclear fuels in general, there are billions of tons of uranium affordably extractable from seawater, versus the amount of helium-3 on the lunar surface usually estimated as on the order of a single million tons, versus trillions of tons of deuterium in earth's oceans alone, plus thousands of quadrillions of tons of deuterium in Jupiter and other gas giants. If ever developed, helium-3 might be the one kind of nuclear power actually having fuel costs be a large component of total expense.
The D-T fuel cycle takes only deuterium and lithium as fuel inputs since the tritium is produced and then consumed in the process. Deuterium is a number of orders of magnitude more abundant than helium-3. Lithium is far cheaper than even deuterium, being a few dollars a kilogram; even lithium-6 is 8% of total lithium, likewise cheap.
Historical thermonuclear bombs have typically been built with primarily lithium-6 deuteride, an exception being the first hydrogen bomb, the Ivy Mike, that used liquid deuterium. A small amount of tritium is used in thermonukes, taking advantage of it being easiest to ignite first.