Sydney Morning Herald wrote:London: Researchers are testing potentially life-saving techniques for keeping humans in a state of suspended animation while surgeons repair their wounds.
US doctors have developed a method of inducing hypothermia to shut down the body's functions for up to three hours.
In tests, they reduced the body temperature of injured pigs from 37C to 10C before operating on them and then reviving them.
Now they are applying for permission to test the procedure on casualty patients without a pulse who have lost large amounts of blood, New Scientist magazine reported.
It is thought this method and others could one day be used on car crash and gunshot victims, as well as in the battlefield to treat wounded soldiers.
A surgeon at Massachusetts General Hospital in Boston, Hasan Alam, has tested the technique about 200 times on pigs, with a 90 per cent success rate.
First he anaesthetises the animal, then cuts a major vein and artery in its abdomen to simulate multiple gunshots to a person's chest and abdomen.
As the pig rapidly loses about half its blood and enters a state of shock, Dr Alam drains its blood and stores it before pumping chilled organ preservation fluid into its system.
The animal's body temperature falls to about 10C until it is in a state of "profound hypothermia" and has no pulse and no electrical activity in its brain.
But after the blood stored earlier is warmed and pumped back into the pig's body its heart starts beating again and it comes back to life.
"It is still pretty awe-inspiring," Dr Alam said. "Once the heart starts beating and the blood starts pumping, voila, you've got another animal that's come back from the other side.
"Technically, I think we can do it in humans."
He now wants automatic consent to use the technique on all patients brought to his hospital who have lost blood and would probably die with only standard care.
Other US researchers are working on methods to place organisms in suspended animation by exposing them to a cocktail of gases, including hydrogen sulphide.
Press Association
How it could work
Physicians would allow a patient to bleed to death within minutes while recapturing the patient¿s blood and replacing it with a cold saline solution, putting the body into a state of suspended animation.
Normal body temperature, 37ºC Hypothermic body temperature, 10ºC
Brain death occurs in 4-5 minutes Brain can survive for 90-120 minutes
At critically low oxygen levels the cellular respiratory chain produces excessive amounts of toxic freeoxygen radicals, killing it¿s own cells.
Hypothermic body temperature, 10c
The saline solution flushes oxygencarrying blood from body tissue, shutting
down the cellular respiratory chain.
For every 10c drop in body temperature, the metabolic rate falls by 50 per cent.
Doctors claim suspended animation success
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Doctors claim suspended animation success
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The theory is sound. The same technique is done on actual hibernating organisms such as squirrels who've had 60% of their whole blood vented as they're in a hibernation state. The body adjusted and kept them alive longer than rats that had the same treatment but weren't in hibernation.
This isn't exactly like cryonic suspended animation which could probably be indefinite. It is, however, a very good thing if you're in ER and lacking in time to get someone specialised to patch you up.
This isn't exactly like cryonic suspended animation which could probably be indefinite. It is, however, a very good thing if you're in ER and lacking in time to get someone specialised to patch you up.
I remember reading about this a while back with zombie dogs. Pretty wild shit. I imagine there's got to be some pretty nasty liability issues with attempting this as "automatic consent." The first person who has all the blood drained out of him intentionally by the doctor and then dies... well, I can imagine the family being struck by a litigious fit, even if the patient would have died anyway.
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I could totally claim to have seen the after-life and start a religion! This kicks ass.
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A 90% success rate. Would that drop with humans due to our larger stature? More blood having to travel further would leave more room for bad things to happen I would think.
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It is an intriguing notion to be sure, and its success will probably depend on how the initial tests on human subjects go. Once precedents have been set and the method has proven beneficial, the theory will gain legitimacy in the eyes of the public, even though there'll probably be some instinctive resistance to the idea of one's mom being pickled in salt water.
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The success rate didn't change from dogs to pigs; but the article doesn't say how big those pigs were (or the dogs for that matter).
If I or someone I cared about was in the situation that conventional techniques couldn't save them, I'd be more upset if they didn't try it. It's the method by which they determine that, though...
Also, if they only try it on real basket cases, the success rate that we see will be the success rate for... the real basket cases. Like, if 20% of them survive, that could be amazing because none would have otherwise. But try telling that to people who think it's too freaky.
If I or someone I cared about was in the situation that conventional techniques couldn't save them, I'd be more upset if they didn't try it. It's the method by which they determine that, though...
Also, if they only try it on real basket cases, the success rate that we see will be the success rate for... the real basket cases. Like, if 20% of them survive, that could be amazing because none would have otherwise. But try telling that to people who think it's too freaky.
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This would certainly make a LOT of surgery easier and safer, assuming they can bring people out of it easily.
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