I read the contributions of a user on SDN thread "The Nature of Palpatine" who offered the conclusion that the decay is a result of "overuse of the dark side of the Force". Is that the official answer? It didn't seem as though Palpatine were performing any mind-boggling Force feats only on rare occasion (i.e., Force Storms, ect.).
The conclusion is also offered that it was immediately the result of the battle with Mace Windu when the lightning was reflected onto his face. Is that true as well? Because it seems that Palpatine's "decay" is slightly noticeable during Attack of the Clones, one notices Palpatine's complexion is much different and nastier even when compared to his canonically older appearance in Return of the Jedi.
This was Luke Skywalker's opinion on the issue (based off of the information of Mara Jade), courtest of Dark Nest I:
Or was it merely a matter that Palpatine wasn't "drawing on the Force" rather than the presence of the dark side was so strong within him, since he is essentially the "dark side avatar" as Publius put it best.The shuddering stopped. Luke continued to maintain both illusions, the Force pouring through him like fire, burning more fiercely every moment. He was drawing more energy than his body was conditioned to endure, literally burning himself up from the inside. It was not really a dark side act -- to a modern Jedi, the dark side was more a matter of intent than deed -- but it felt that way to him. According to Mara, this is what happened to Palpatine, and Luke believed her.