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GrandMasterTerwynn
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Post by GrandMasterTerwynn »

Justforfun000 wrote:
No they don't. The only difference between processed herbs and "natural" ones is potency, due to the processing. The only reason they would work differently is if they had additives or extra stuff tossed into or removed from the process to make them.
You're wrong. There has been evidence showing that only herbs possess "adaptogenic' properties.

Here's just one example of this:

http://ecam.oxfordjournals.org/cgi/cont ... tanbul.Com

Adaptogenic Potential of a Polyherbal Natural Health Product: Report on a Longitudinal Clinical Trial
Dugald Seely1,2 and Rana Singh1

1The Canadian College of Naturopathic Medicine ON, Canada and 2Institute of Medical Science, University of Toronto ON, Canada
College of Naturopathic medicine . . . wait, what? I'm smelling something.
We conducted an open-label longitudinal study on the natural health product, OCTA©, a compound mixture of eight herbs, to determine its effects on perceptions of stress.
Open-label. So the participants know what they're getting. Yep, definitely smelling something here, and it doesn't smell good.
Eighteen participants were enrolled in the study and were followed over a period of 3 months. Primary endpoints included scores from four validated questionnaires (SF-36v2, PSS, STAI and BDI-II), serum DHEA, ALT, AST and creatinine all measured at 12 weeks. Seventeen patients completed the study. Except for the physical summary score of the SF36
In short, it seems to have had no physical effect on the participants in the study. I'm pretty sure I know what that smell is.
questionnaire, all the subjective scores indicated a highly significant (P < 0.0001) improvement in the participants' ability to cope with stress.
Oh I know that smell. It's . . . bullshit! In short, what they did was give them some combination of herbs that allegedly allow them to cope with stress. The study is open-label, so both study administrators and study participants know this. And, subjectively, they feel better.

In short, they've rediscovered the placebo effect.

Below, I shall bold the part that you should've bolded, rather than the part you actually did:
No adverse effects were reported and there was no evidence of damage to the liver or kidney based on serum markers. Initial evidence for this polyherbal compound supports its potential as an effective ‘adaptogenic’ aid in dealing with stress. Further research using a randomized controlled design is necessary to confirm the findings from this pilot study.
Which demonstrates that the study you cited, in fact, demonstrates that what they've discovered is the placebo effect, rather than some demonstrable effect of the herbs themselves. Typical of so-called "naturopathic" flim-flam.
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Justforfun000
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Post by Justforfun000 »

Which demonstrates that the study you cited, in fact, demonstrates that what they've discovered is the placebo effect, rather than some demonstrable effect of the herbs themselves. Typical of so-called "naturopathic" flim-flam.
Fair enough. I honestly didn't look at it that carefully. I was just looking for examples of adaptogenic.
This IMO attempts to insert a false barrier between drugs and herbs. There isn't any real difference. What you're talking about is simply prophylaxis, and there certainly ARE drugs intended for that purpose.

Again, why is prune juice now somehow a herb? My real contention here, why is there this artificial division between medicine? Allopathy vs herbal/complementary? There ISN"T ANY.
I don't agree with you here and neither does the industry. Herbs are far safer in general then drugs. You keep trying to state that there is no real difference between them, but that's bullshit! There are millions that use these products regularly, and people aren't being harmed or killed by using them. There are thousands of people dying of prescribed drug use every year. Here's another news article regarding the new bill:

Canadian Health Food Association (CHFA) lobbying hard to amend current bill C-51
(Drinks Media Wire). CHFA meets with Elected Officials and Health Canada to call for a major overhaul in Food & Drugs Act

Today, the Canadian Health Food Association (CHFA) launched a postcard lobby campaign to build on the association’s recent advocacy efforts aimed at addressing member concerns about Bill C-51.

“While CHFA supports the government’s commitment to ensuring Canadians are provided with foods and products that are safe and effective, our members cannot support legislation that categorizes Natural Health Products (NHPs) as therapeutic products together with drugs and medical devices,” said Penelope Marrett, CHFA President and CEO. “This bill views NHPs through the lens of pharmaceutical drugs and that is just not right for consumers.”

CHFA has met with numerous Members of Parliament and officials over the last few weeks including testifying before the House of Commons Standing Committee on Health and meeting with the Parliamentary Secretary to the Minister of Health. The aim has been to educate M.P.s about the need to create a separate category for NHPs that recognize their low risk nature and that the current Regulations and their interpretation need to reflect the low-risk nature of NHPs and their demonstrated benefits.

“Canadians want to have continued access and choice to high quality and effective Natural Health Products, said Marrett. “ The government has a responsibility to ensure that any amended legislation recognizes that NHPs are neither foods nor drugs. And that access to these important products will continue now and into the future to be available to Canadians working to achieve optimal health and well-being.”

CHFA continues to lobby hard with Parliamentarians to remind them that cross-Canada hearings in the mid 1990s led the Standing Committee on Health to conclude that NHPs were neither food nor drugs, which required a separate definition under the Act and unique regulations. In 2004, the Natural Health Product Regulations came into force.

“We have had very positive meetings with government to date on this issue and have heard the Minister’s support for Natural Health Products in the House of Commons,” added Penelope Marrett. “The fact is, we need the appropriate legislative and regulatory action to match these commitments and make sure we have a system that truly serves Canadians.”

For more information on the postcard campaign and NHP and Organics industry, visit www.chfa.ca
Of course drug testing is meant to isolate active ingredients. May I point out that vitamin supplements are deliberately DESIGNED so that neccessary co-factors are present, so that optimal uptake and effiency is present? Vitamin D and Calcium are prime examples of this, and I absolutely REFUSE to subscribe to your artificial barrier between supplements/herbs/drugs. Its not as if doctors and pharmacists don't titrate your prescription to meet your needs.

This is not the same as cofactors present in herbs. those are completely different compounds that are put together because they are synergistic, but the aren't the same as a full makeup of an entire herb and it's constituents.
That's the exact same argument the drug industry raised in the 19th century, and its demonstrably false then. Sorry, but a massive removal of junk and noise can only be GOOD for the consumer. Stronger product testing can only be GOOD for the consumer.

IF they are able to afford the clinical trials and recoup the investment. And also if they do not cause delay or removal of said products before they "pass".
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Post by Justforfun000 »

Oops. Reversed the last few quotes...oh well, I'm sure you can tell which are which.

By the way Painrack, you keep suggesting prevention methods in conventional methods are comparable to 'alternative' medicine, but it's not the same thing. It's always been general good medicine to avoid harmful things like alcohol and smoking, and also to promote exercise and relaxation.
But conventional method does not recommend herbal products per se because they simply aren't legislated as drugs and are therefore not in the arsenal of physicians although a lot of them are personally aware of them and suggest them off the record.
You have to realize that most Christian "moral values" behaviour is not really about "protecting" anyone; it's about their desire to send a continual stream of messages of condemnation towards people whose existence offends them. - Darth Wong alias Mike Wong

"There is nothing wrong with being ignorant. However, there is something very wrong with not choosing to exchange ignorance for knowledge when the opportunity presents itself."
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Post by Justforfun000 »

Here's a better compilation of adaptogenic herbs. They give an overview of the controlled studies and their conclusions:
Re: Adaptogenic Herbs in Clinical Practices

Abascal K, Yarnell E. Increased vitality with adaptogens. Alternative & Complementary Therapies. 2003; April:54-60.

In this article, the authors discuss adaptogens, herbs which are not generally used for specific ailments, but as tonics may help patients achieve better health. A sidebar in the article summarizes uses and doses of the herbs included. Adaptogenic herbs have been found to benefit both those who have a stream of minor ailments and those with chronic diseases. They alleviate both physical and mental stress and may stimulate a non-specific stress response via the hypothalamic-pituitary-adrenal systems.

American ginseng (Panax quinquefolius) was used as a tonic by Native American tribes. Overharvested in the wild, organic, woods-cultivated American ginseng products are now available. In the past, cultivation under other conditions may result in products with fungicide and other residues. American ginseng has shown hypoglycemic action in clinical studies of patients with type 2 diabetes and has had other beneficial effects on diabetic patients. With ginkgo (Ginkgo biloba), it has reduced hyperactivity in children with attention deficit hyperactivity disorder. In vitro and animal studies have found antioxidant and immunoenhancing effects. In animals, it has been shown to be neuroprotective and memory-enhancing. American ginseng has antineoplastic effects and has been found to enhance the effects of most breast cancer chemotherapy drugs in vitro. The authors use American ginseng in their clinical practice to help middle-aged men and women handle midlife stressors and for older patients suffering from the results of earlier poor lifestyle choices, women experiencing menopausal symptoms, and those with breast cancer. The authors state that the breadth of research on and uses of this herb partly explain why it is considered an adaptogen.

While Abascal and Yarnell say that there have not been very many studies that have tested the use of adaptogens as such, they cite fewer studies on Asian ginseng (Panax ginseng) than might be expected. Like other adaptogens, its efficacy for any particular condition has yet to be proven. However, Asian ginseng extracts reduced stomach, lung, and liver cancers in a case-controlled study in Korea; in another study, combined with conventional treatment and other herbs, it improved survival in patients with small-cell lung cancer. Research into Asian ginseng's reputed ability to enhance physical endurance has produced mixed results. Some studies have found it superior to trazodone for erectile dysfunction. It has also been found to raise men's sperm counts. A long-term controlled study found that it benefited patients with human immunodeficiency virus. Animal and in vitro studies have found Asian ginseng and/or its components to be antineoplastic, antiulcerogenic, and radioprotecive. The authors use Asian ginseng for patients weakened by age or serious disease, but also express concern about fungicide and pesticide residues in commercial supplies (organic Asian ginseng is virtually nonexistent).

Eleuthero (Eleutherococcus senticosis; formerly called Siberian or Russian ginseng), has been used to increase vital energy, improve sleep quality, improve appetite, treat back pain and rheumatoid arthritis, and may be the best-studied adaptogen. However, most of the existing research is in Russian. Studies of over 6,000 people tested eleuthero's ability to improve mental alertness, work output, and work quality in individuals with difficult working conditions or requirements with generally positive results. In one study of children with acute dysentery, those who received eleuthero and monomycin recovered more quickly than those receiving monomycin alone. Eleuthero is not traditionally used for acute conditions. Other studies have found that eleuthero may be useful in pneumonia, pyelonephritis, or cancer. The authors use eleuthero for younger patients suffering from stress or for athletes seeking alternatives to steroids.

Schisandra (Schisandra chinensis) berries are used traditionally for nervous conditions, coughs, liver ailments, and depleted fluids. It enhances immune responses, and reduces fatigue and sleeplessness. In vitro and in vivo studies have found schisandra and its constituents to be neuroprotective, hepatoprotective, cardioprotective, renal-protective, antineoplastic, antioxidant, and immune-enhancing. It has stimulated liver regeneration, produced strong antihepatitis-C activity, enhanced cognition and memory in animals, and improved endurance. A sweet schisandra glycerite is useful for children who need an adaptogen. The authors use it for patients with chronic liver or heart ailments and for menopausal women and others experiencing night sweats.

Ashwaganda (Withania somnifera) root is a traditional general tonic for energy and health and a component of Ayurvedic formulas for arthritis, rheumatism, and disease prevention in both elderly and pregnant individuals. A double-blind, placebo-controlled, crossover study of 42 patients with osteoarthritis found that ashwaganda, in conjunction with other herbs, reduced pain and disability significantly. Other studies found improved hemoglobin levels in healthy children and adult men. Ashwaganda has stimulated neurite growth in human brain cells. In animals and in vitro, it has stimulated thyroid function, increased endurance, and shown hepatoprotective, renal-protective, antineoplastic, cardioprotective, anti-inflammatory, antioxidant, and immunomodulating effects. The authors use ashwaganda for low libido in patients suffering from stress or anxiety, those with arthritis, and for elderly patients with dementia.

Rhodiola (a.k.a. golden root, Arctic root; Rhodiola rosea) is used in mainstream Russian medicine for fatigue, infection, and psychiatric and neurological conditions, and, in healthy individuals, to relieve fatigue and to improve concentration, memory, and productivity. (See HC 040233.241.) Traditional uses include enhancing fertility, speeding adaptation to high altitudes, and treating gastrointestinal ailments and infections. In open and double-blinded human studies, rhodiola reduced fatigue, insomnia, weakness and headache; improved quality and quantity of work; and improved general well-being. Animal and in vitro studies have found antioxidant, cardioprotective, anticarcinogenic, and strengthening effects. The authors use rhodiola for individuals whose stress and fatigue stems from intellectual work, including students; for those who have trouble concentrating; and for insomnia.

Several Aralia species, closely related to the ginsengs, are found in the U.S. and Asia. Asian aralias have been found to induce phase II enzymes in vitro, to be antioxidant, to normalize kidney function in diabetic rats, and to be hypoglycemic. Not enough is known of American aralias' constituents to determine if these same results might be found with their use. Following Michael Moore, director of the Southwest School of Botanical Medicine (Bisbee, AZ), the authors use aralia for patients with chronic lung problems. Either roots or berries are used; the berry tincture has a more pleasant taste.

Devil's club (Oplopanax horridum) is a member of the Araliaceae family. Used by Native Americans for rheumatism; stomach and bowel cramps; coughs, colds, and various pulmonary disorders; and as a purgative, some tribes used it to promote weight gain and as a blood tonic while others used it for diabetes. There is little research on devil's club. It has been found to inhibit various bacterial, viral, and fungal species. Again following Moore, the authors use devil's club in type 2 diabetes and for young women with recurring yeast (Candida albicans) infections. Moore also recommends it as an expectorant and respiratory stimulant, and for people with rheumatoid arthritis and other autoimmune disorders.

In summary, the authors write that stress is the root of most modern ailments. Adaptogens - those discussed and others - may help patients overcome stress. While differing subtly, they are, "in many respects, interchangeable and a high quality but less specific...product will usually work better than a lower quality product that matches...a patient's condition more exactly."
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Post by General Zod »

Justforfun000 wrote: I don't agree with you here and neither does the industry. Herbs are far safer in general then drugs. You keep trying to state that there is no real difference between them, but that's bullshit! There are millions that use these products regularly, and people aren't being harmed or killed by using them. There are thousands of people dying of prescribed drug use every year. Here's another news article regarding the new bill:
According to what, your say so? How about long-term side effects? How do you know it's actually doing what it's supposed to? You can't gauge that sort of thing without double-blind clinical trials.
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Post by Justforfun000 »

According to what, your say so? How about long-term side effects? How do you know it's actually doing what it's supposed to? You can't gauge that sort of thing without double-blind clinical trials.
You don't think the news would have a field day if people were dying by these herbs? Even long-term side effects would be easily spotted by reporting. The difference with herbs is unlike new drugs, MILLIONS of people are using them. And there ARE double-blind clinical trials in other countries like Germany for some products.
You have to realize that most Christian "moral values" behaviour is not really about "protecting" anyone; it's about their desire to send a continual stream of messages of condemnation towards people whose existence offends them. - Darth Wong alias Mike Wong

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Post by General Zod »

Justforfun000 wrote: You don't think the news would have a field day if people were dying by these herbs? Even long-term side effects would be easily spotted by reporting. The difference with herbs is unlike new drugs, MILLIONS of people are using them. And there ARE double-blind clinical trials in other countries like Germany for some products.
How is reporting after the fact a superior preventative to double-blind clinical studies? I also wasn't aware appeals to popularity was a valid argument. You could have millions of people hooked on sugar pills for a placebo effect too, but that wouldn't make them inherently safe or proven effective.
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Post by Justforfun000 »

How is reporting after the fact a superior preventative to double-blind clinical studies? I also wasn't aware appeals to popularity was a valid argument. You could have millions of people hooked on sugar pills for a placebo effect too, but that wouldn't make them inherently safe or proven effective.
Sigh..normally Appeals to Authority is a poor argument, but in this case the unique facts change the picture a little. Preponderance of evidence is a lot more compelling in this instance then a lack of reports showing harm or fatality. They know it's not the palcebo effect because they are affecting specific functions of the body. I highly doubt the placebo effect is so powerful that by suggesting they are taking liver protecting herbs they actually mentally boost their liver's capability and show reduced ALT & AST enzymes.

I still stand by the arguement that herbs really are in a different class of medicine and should be treated accordingly. They deserve a bit of slack for being used for so long without serious challenge. That in itself bespeaks first and foremost a general sense of safety.

Kava Kava was a very new herb to this continent and it was a wonder one for a while. But it didn't take long to discover reports of liver damage. They didn't need the double-blind study. The anectdotal results were enough to flag it and they gave it a serious inquiry. So that's one, and they caught it fast. How many drugs slip through that constantly pass surveillance even with all their expensive trials? Most traditional herbs in general are demonstrably less toxic in nature and have withstood the test of time admirably and have continued to do so even when more serious studies have been performed. I (as others) believe that this grants them the right to an exemption of the pharmaceutical level of standards needed to become a drug. They go above and beyond the pale, and because they can be very toxic and powerful, it is warranted.
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Post by Justforfun000 »

Oh and I'm heading to Vegas tomorrow for a week so I'll likely miss any arguements after this for awhile. Wish me luck. :wink:
You have to realize that most Christian "moral values" behaviour is not really about "protecting" anyone; it's about their desire to send a continual stream of messages of condemnation towards people whose existence offends them. - Darth Wong alias Mike Wong

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Post by Broomstick »

Justforfun000 wrote:Kava Kava was a very new herb to this continent and it was a wonder one for a while. But it didn't take long to discover reports of liver damage. They didn't need the double-blind study. The anectdotal results were enough to flag it and they gave it a serious inquiry.
They didn't need anecdotes, either - they just had to listen to the natives who never, ever combined it with alcohol and warned the white people trying it to not mix the two.

Liver damage from kava kava is associated with two things: alcohol consumption, and poor processing. The latter is a problem because supplements are not as strongly regulated, and the former is a problem because altogether too many Westerners treat supplements as if there are no risks and side effects. Since the traditional beverage means of preparing is unappealing to most westerners it is typically put into capsules, which requires processing that, in this case, raised the risk of problems.
Most traditional herbs in general are demonstrably less toxic in nature and have withstood the test of time admirably and have continued to do so even when more serious studies have been performed.
Really? Including formulations containing things like mercury and arsenic compounds found in both traditional Chinese and ayurvedic medicines?
I (as others) believe that this grants them the right to an exemption of the pharmaceutical level of standards needed to become a drug. They go above and beyond the pale, and because they can be very toxic and powerful, it is warranted.
Herbal medicines can also be powerful, toxic, harm certain populations due to risk factors, and can combine with other things (such as alcohol) to cause harm. There should be some regulation there.
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Justforfun000 wrote: Fair enough. I honestly didn't look at it that carefully. I was just looking for examples of adaptogenic.
If you had looked at the end which stated further research part, you would had noticed that it outright said that it needed further study to show that this wasn't a placebo effect.
I don't agree with you here and neither does the industry. Herbs are far safer in general then drugs.
Only in the sense that herbs are lower doses. That's a no shit statement. You play around with smaller doses, obviously, any side-effects you get are going to be less severe. I would like to point out that Ma Huang itself is cardiogenic and in herbal form has been linked to possible cardiac attacks.
You keep trying to state that there is no real difference between them, but that's bullshit!
Really? So pray tell. How on god earth are these CHEMICALs different?
Is there some special niche of chemicals that Herbs fall into and drugs don't? Do they all utilise some form of special action that drugs don't? You do know what IS the difference between food and drugs right? The sole difference, repeat, sole difference, is that food provide energy. Drugs don't. When discussing the difference between vitamins and drugs, it become even more blur. Drugs are used for therapeutic effect and vitamins are certainly used in that manner, when prescribed to balance nutritional deficit or bodily functions deficit/requirements.
There are millions that use these products regularly, and people aren't being harmed or killed by using them. There are thousands of people dying of prescribed drug use every year. Here's another news article regarding the new bill:
So, medication error leads to death. If that's so, why not included cynaide poisoning from alternative treatments, including the infamous apricot laetrile?
This is not the same as cofactors present in herbs. those are completely different compounds that are put together because they are synergistic, but the aren't the same as a full makeup of an entire herb and it's constituents.
Pray tell. HOW? You need calcitriol and vitamin D to make it into the active form. Tada!
Synergy!
IF they are able to afford the clinical trials and recoup the investment. And also if they do not cause delay or removal of said products before they "pass".
And any company which can provide good QC/QA obviously has the resources to do so. Again, may I remind you that this argument is NO DIFFERENT from those raised in the 19th century?

You don't think the news would have a field day if people were dying by these herbs? Even long-term side effects would be easily spotted by reporting. The difference with herbs is unlike new drugs, MILLIONS of people are using them. And there ARE double-blind clinical trials in other countries like Germany for some products.
Really? Let me repeat this name again. Huo Yuan Jia. Huo Yuan Jia. Huo Yuan Jia.

Ok. Done

And I also like to point out that the dangers involved has been repeatedly stated before. Let me see, laetrile? Cyanide poisoning. Ephedra? Oh dear.... cardiogenic factor, link to increased risk of cardiac arrest in vulnerable patients, thus, leading the American authorities to remove this as a weight loss supplement.
Sigh..normally Appeals to Authority is a poor argument, but in this case the unique facts change the picture a little. Preponderance of evidence is a lot more compelling in this instance then a lack of reports showing harm or fatality. They know it's not the palcebo effect because they are affecting specific functions of the body. I highly doubt the placebo effect is so powerful that by suggesting they are taking liver protecting herbs they actually mentally boost their liver's capability and show reduced ALT & AST enzymes.
And again, how on earth is this different from ANY DRUG? Lipitor reduces cholesterol. Same fucking thing. You're just insisting that hey, herbs have magical effects beyond the laws of fucking chemistry, and thus they should be treated differently from drugs which are bound by physical laws!
Hey, tell you what. Let's discuss about this synergy. How is it done? Is it done because of protein transport? Increased uptake? Binding of competiting agents/receptors? Reduced acidity of stomach so that agent has increased bio-availabilty? Let's talk science. TELL ME. HOW DOES THIS SYNERGY COMES ABOUT? If its some revolutionary new method, TELL US. How does this action/mechanism come about? Admiral Valdamer handles this stuff. He could certainly guide us and show me the errors of my way.
By the way Painrack, you keep suggesting prevention methods in conventional methods are comparable to 'alternative' medicine, but it's not the same thing. It's always been general good medicine to avoid harmful things like alcohol and smoking, and also to promote exercise and relaxation.
But conventional method does not recommend herbal products per se because they simply aren't legislated as drugs and are therefore not in the arsenal of physicians although a lot of them are personally aware of them and suggest them off the record.
Outright red herring. I stating that your claim that only HERBS are used for preventive medicine and conventional medicine ignores this is an outright fallacy.

And even if you wish to discuss this on a purely pharmaceutical manner(which is fucking insane), conventional medicine has the triad of hypertensive drugs=(reduce cardiac disease and stroke), anti-cholesterol drugs=(reduce risk of IHD) and glycaemic drugs(reduce risk of complications from poor blood sugar control, ranging from microvascular to macrovascular damage)

And of course, this ignores the fact that doctors routinely prescribe vitamin B complexes, folic acid and iron tablets. Hell, I get freaking iron tablets every time I donate blood even though I'm an 88kg male who's obviously over-eating. And let's not forget, they're even inventing drugs to combat obesity, even though this begs the issue of medicalisation and pill popping mentality IMO.
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Post by Justforfun000 »

Just returned from Vegas. Not ahead, but lots of fun!

Ok...lets see:

Broomstick Wrote:
Liver damage from kava kava is associated with two things: alcohol consumption, and poor processing. The latter is a problem because supplements are not as strongly regulated, and the former is a problem because altogether too many Westerners treat supplements as if there are no risks and side effects. Since the traditional beverage means of preparing is unappealing to most westerners it is typically put into capsules, which requires processing that, in this case, raised the risk of problems.
Really? I wasn't aware it was caused by the mixing with alcohol. I thought they were just discovering the effects from the Kava alone. If that's the case though, why did they ban the sale? I would have thought they would have to specifically target the Kava as the problem...many things can cause liver damage mixed with alcohol. Tylenol is a great example and it's totally OTC.
Really? Including formulations containing things like mercury and arsenic compounds found in both traditional Chinese and ayurvedic medicines?
I was referring more to "western" herbs and the major companies that have been selling them for decades. Asian/Indian herbs and their production have always been manufactured and processed under a far lesser standard of quality then North America or Europe as a whole.
Herbal medicines can also be powerful, toxic, harm certain populations due to risk factors, and can combine with other things (such as alcohol) to cause harm. There should be some regulation there.
Agreed. Of course everything depends on WHAT herb as well. Obviously Foxglove and Wolfsbane should not be sold promiscuously. We get Digitalis and Aconite from both respectively and they are extremely powerful and potentially dangerous.

There is a general group of herbs that are now well known and at the very least minimally evidential and relatively benign to the best of our knowledge. This includes Garlic, Milk Thistle, De-Glycyrrhizinated Licorice, Bilberry, Grape Seed Extract, Ginko Biloba, etc. etc.

It's these ones that people are concerned about and I do not think it would be fair to pass a bill like C-51, remove ALL of these from the shelves until 'someone' puts them through the drug trials, and ban consumers from purchasing or possessing these until they become approved. That's the entire crux of my point, and the other people in Canada who does not feel the government should have the right to retroactively re-classify these particular type of products as "investigational drugs".

PainRack Wrote:
If you had looked at the end which stated further research part, you would had noticed that it outright said that it needed further study to show that this wasn't a placebo effect.
Yes, I should have read it more carefully. Originally I was just trying to find a description in practice of the concept 'adaptogenic'. It's specifically attributed to herbs alone and that's why I was looking for evidence explaining why herbalists feel that they ARE unique and not as simple as drugs.
Only in the sense that herbs are lower doses. That's a no shit statement. You play around with smaller doses, obviously, any side-effects you get are going to be less severe. I would like to point out that Ma Huang itself is cardiogenic and in herbal form has been linked to possible cardiac attacks.
No I don't believe that that's correct. The size of the dose does not seem to have a direct correlation to harmful potential. For example the effects of licorice as a canker sore treatment, (brand new study just out today in the news), shows great efficacy with no serious sides.

http://www.medicalnewstoday.com/articles/108567.php

Licorice Extract Provides New Treatment Option For Canker Sores
25 May 2008

What common oral condition appears as shallow ulcers of different sizes, affects one in five Americans, can be caused by food allergies and hormonal changes, and also can cause severe mouth pain? Commonly referred to as "canker sores," recurrent aphthous ulcers (RAU) now can be treated by an extract in licorice root herbal extract, according to a study published in the March/April 2008 issue of General Dentistry, the Academy of General Dentistry's (AGD) clinical, peer-reviewed journal.

The authors examined the effects of an over-the-counter medicated adhesive patch (with extract from the licorice root) for treatment of RAU versus no treatment. After seven days of treatment, ulcer size in the group who received the adhesive patch with licorice extract was significantly lower, while ulcer size in the no-treatment group had increased 13 percent.

Licorice root extract was used as a prescribed treatment for gastric ulcers until the 1970s, according to the study. In its original form, licorice root extract has a very strong taste. However, when combined with a self-adhering, time-release, dissolving oral patch, the taste is mild and pleasant.

Among the causes of canker sores, a genetic predisposition might be the biggest cause, says Michael Martin, DMD, PhD, lead author of the study. "When both parents have a history of canker sores, the likelihood of their children developing them can be as high as 90 percent," he says.

The most serious side effect of canker sores is sharp pain in the mouth, which can interfere with an individual's quality of life and affect their eating, drinking or speech. Dr. Martin revealed that "in addition to speeding healing of the canker sores, the adhesive patch helped to reduce pain after just three days of treatment."

Those who experience canker sores on a regular basis can visit their dentist for treatment techniques. "Dentists can give patients the proper medication and treatment options to seal the lesions, which will prevent further infection," says Eric Shapira, DDS, MAGD, AGD spokesperson and expert on alternative medicine. "Also, increasing vitamins and other herbs, such as Vitamin C and zinc, can help treat canker sores because they help to regenerate tissue cells," Dr. Shapira adds.


Ma Huang is an herb that needs a bit more caution. It is weaker then Ephedrine as an isolate, true, but it is an herb that leans a bit more towards the drug side in comparison of action, especially with symptomatic relief of congestion. Obviously as you point out it has other potential concerns. Obviously I'm not trying to suggest all herbs should be exempt from scrutiny. We don't need to create a false dilemma here where we choose between all herbs being regulated as drugs or none of them being controlled whatsoever. I'm saying that the onus should be on the government to provide reasons to proscribe certain herbs based on evidence of toxicity or misuse. I don't believe the default should be on someone in the industry to prove the herb is safe and pharmaceutically as effective as a drug through millions of investment dollars that they will NOT be able to patent for themselves.

Really? So pray tell. How on god earth are these CHEMICALs different?
Is there some special niche of chemicals that Herbs fall into and drugs don't? Do they all utilise some form of special action that drugs don't?
Yes! They are an entire plant and sometimes food is our medicine. Herbalists suggest for most diseases, there is an herb and while we may not have every single thing lined up for all conditions, they have been fairly accurate at finding something to aid most human conditions. There is no doubt that the planty world has many things to offer us in treating our bodies and their disorders. One would almost think it was 'designed' this way to have a growing pharmacopeia in the world to meet our needs.

As I've said before, herbalists profess that herbs as a whole have a method of action that is more comprehensive and demonstrably less inclined to side effects when used as an entire product with the active ingredients located and standardized, (like Milk thistle at 80% Silymarin, calculated as Silybin), compared to isolating and extracting the prime ingredient they believe is mainly the active principle. Supposedly previous attempts to do this has demonstrated exactly that. Some degree of action, but a much higher incidence of side effects and no suggestion of an adaptogenic property any longer that would temper it's action in the human body based on your needs.
You do know what IS the difference between food and drugs right? The sole difference, repeat, sole difference, is that food provide energy. Drugs don't. When discussing the difference between vitamins and drugs, it become even more blur. Drugs are used for therapeutic effect and vitamins are certainly used in that manner, when prescribed to balance nutritional deficit or bodily functions deficit/requirements.
But this does not mean that our current dictionary classification is CORRECT. It is probably incomplete because to start with, almost anything can fall under the category of a drug when taking the simple definition of Merriam's Dicitonary : (3): a substance other than food intended to affect the structure or function of the body.

Other's have more specific definitions, but that is one of them listed above and it is VERY broad.
So, medication error leads to death. If that's so, why not included cynaide poisoning from alternative treatments, including the infamous apricot laetrile?
Rare cases of individual products does not justify tarring all with the same brush. In your example it's not even an herb. It's an extraction from the pit of a fruit. Obviously some things deserve regulation and attention. Same as extracting Vincristine from a periwinkly. That one is arguably food, but it's got the properties of a drug. This is why lines cross here and I again do not agree with them trying to ham fistedly blanket the entire herbal and natural products industry with a pharmaceutical lens. There should be a much more moderate approach to this subject and finding the middle ground between protecting the public from harm and false claims and indiscriminately raising the bar for every single substance to the necessary standards of a pharmaceutical drug needs to be found.
Pray tell. HOW? You need calcitriol and vitamin D to make it into the active form. Tada!
Synergy!
But the point here is in many cases the "HOW" is already done for you. Herbs are grown into a useful combination by virtue of their nature. However to be fair sometimes you DO need to remove some other constituents....Ricin from Castor Oil is one thing that comes to mind..
And any company which can provide good QC/QA obviously has the resources to do so. Again, may I remind you that this argument is NO DIFFERENT from those raised in the 19th century?
The argument may not be any different, but the fact remains that they CAN patent their drug product once trials are complete and this is not the same for natural products. This is the singular most important point to this discussion because it completely changes the playing field between a drug and an herb. That is unless they treat it like a drug. Extract the "active" ingredient and fiddle with it in some way so they can ultimately patent it, but then just like other substances like Digitalis or Vincristine, presto. You have a drug. No longer an herbal product. So what's different here? We still cannot use the original product and it's gentler method of action (in cases where that claim is warranted), and also it's undoubtedly going to be hugely more expensive and need to be prescribed.

Again, the consumer loses.

.
Really? Let me repeat this name again. Huo Yuan Jia. Huo Yuan Jia. Huo Yuan Jia.
Why should this be a counter to my argument? Have you read this?

Huo Yuanjia became seriously ill and passed away on August 9th, 1910 at 42 years of age (some say he died the 14th of September 1910). When and how he died is still debated and is shrouded in mystery. It is rumored that he had been poisoned by the Japanese as revenge for their defeat during the Judo competition but this is speculation. Some people believe that Huo Yuanjia may have died due to incorrect changes made to his medicine and incorrect treatment by his new Chinese doctor. Others speculate that the European colonists were threatened by the rise of Chinese nationalism and had him poisoned

With no clear evidence on what or who was responsible, I'd hardly say this was a convincing anectdote. Especially since some feels he mau have been deliberately killed.
And I also like to point out that the dangers involved has been repeatedly stated before. Let me see, laetrile? Cyanide poisoning. Ephedra? Oh dear.... cardiogenic factor, link to increased risk of cardiac arrest in vulnerable patients, thus, leading the American authorities to remove this as a weight loss supplement.
And as I stated before, when there IS clear indication of harm, by all MEANS remove said herb. But why kill them many for the few?
And again, how on earth is this different from ANY DRUG? Lipitor reduces cholesterol. Same fucking thing. You're just insisting that hey, herbs have magical effects beyond the laws of fucking chemistry, and thus they should be treated differently from drugs which are bound by physical laws!
Because the drugs have MUCH more likelihood of side effects. Many herbs taken to lower cholesterol like Garlic, do not have anywhere NEAR the sides commonly found in drugs like Lipitor. Same with taking celery salt for high blood pressure. Observe:

Celery Seed Extract standardized to contain 85% 3-n-butylphthalide (3nB). 3nB is a compound that is unique to celery and is responsible for the characteristic flavor and odor of celery. 3nB was discovered as the active component of celery in response to investigations by researchers seeking to explain some of the medicinal effects of celery including the lowering of blood pressure and the relief of arthritis. 3nB first drew significant scientific attention when researchers at the University of Chicago Medical Center identified it as the factor in celery responsible for the blood pressure lowering effect of celery. The research was prompted by one of the researcher's father, who after eating a quarter-pound of celery every day for one week observed his blood pressure dropped from 158 over 96 to a normal reading of 118 over 82. Subsequent animal studies found that a very small amount of 3nB lowered blood pressure by 12 to 14% and also lowered cholesterol by about 7%. It appears to have a similar effect in humans at a dosage of 75 to 150 mg twice daily.

So I'm not just saying that whole herbs are in many cases different because of the concept of adaptogenic capability, but overall in MOST cases are far more likely to be non-toxic even when used at a dosage that is clearly therapeutic. It may not be magic, but it's a wonder of nature.
Hey, tell you what. Let's discuss about this synergy. How is it done? Is it done because of protein transport? Increased uptake? Binding of competiting agents/receptors? Reduced acidity of stomach so that agent has increased bio-availabilty? Let's talk science. TELL ME. HOW DOES THIS SYNERGY COMES ABOUT? If its some revolutionary new method, TELL US. How does this action/mechanism come about? Admiral Valdamer handles this stuff. He could certainly guide us and show me the errors of my way.
I canot answer this. I can only point out what others have discovered as conclusions, not the full mechanisms of action. But this is not much different then many drugs. They STILL do not fully understand how aspirin works and it's one of the most well-studied and commonly used drugs in existence today.

Hopefully we will discover the answer to this and more, but until then, we don't need to dismiss effectiveness in action just because we don't understand the mechanism behind it.
Outright red herring. I stating that your claim that only HERBS are used for preventive medicine and conventional medicine ignores this is an outright fallacy.
Well if I did I'm sorry, no they are not the ONLY things used for preventative, but they do tend towards a much larger percentage of that category then most pharmaceutical drugs.

And even if you wish to discuss this on a purely pharmaceutical manner(which is fucking insane), conventional medicine has the triad of hypertensive drugs=(reduce cardiac disease and stroke), anti-cholesterol drugs=(reduce risk of IHD) and glycaemic drugs(reduce risk of complications from poor blood sugar control, ranging from microvascular to macrovascular damage)
This is true, but the argument here is that all of these drugs tend to have unwanted sides and in many cases can be harmful albeit at an acceptable risk to benefit ratio, whereas many herbs are touted to be EQUALLY as effective sometimes, and yet far less likely to be harmful or rife in sides. This in many cases still needs to be proven absolutely, but most preliminary or intermediate studies seem to bear this out very well for most herbs.

I really believe that they do deserve to be in a special category. Somewhere in the middle would be ideal for regulation.

I enjoy your points and you really do get me thinking a lot more in depth about this in any event. I've always admired your posts, so by all means if you still think I'm missing something, hammer away at me. Maybe you'll get me to change my mind, but so far I really do see this from the side of the people wanting to use herbs they feel are safe and effective without government interference causing a dramatic withdrawal of hundreds of products.
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Justforfun000 wrote:
Broomstick wrote:Liver damage from kava kava is associated with two things: alcohol consumption, and poor processing. The latter is a problem because supplements are not as strongly regulated, and the former is a problem because altogether too many Westerners treat supplements as if there are no risks and side effects. Since the traditional beverage means of preparing is unappealing to most westerners it is typically put into capsules, which requires processing that, in this case, raised the risk of problems.
Really? I wasn't aware it was caused by the mixing with alcohol.
Oh, yes, it's been known for quite some time that kava kava + alcohol = Bad Idea. In fact, the natives from which kava kava was first obtained knew this, and have long been adamant that one should not mix the two.

There is also some evidence that people with liver damage can also be adversely affected by using kava kava. When you consider that some folks have Hep C and don't know it until the liver damage is quite extensive, you can wind up with some bad situations.

That said, kava kava is still available here in the US. It is not as easily found as it once was, but still obtainable.
I thought they were just discovering the effects from the Kava alone. If that's the case though, why did they ban the sale?
Because, at least in part, it was deemed far easier to ban kava kava in Western populations than to attempt to ban alcohol. Kava, after all, is a tropical plant and thus for the most part can only be obtained through import, which means it is much easier to control than alcohol.
I would have thought they would have to specifically target the Kava as the problem...many things can cause liver damage mixed with alcohol. Tylenol is a great example and it's totally OTC.
Yes, and it causes a lot of problems. I've heard that as many as 2/3 of liver transplants due to acute causes is from mixing acetaminophen/paracetamol and alcohol.
Really? Including formulations containing things like mercury and arsenic compounds found in both traditional Chinese and ayurvedic medicines?
I was referring more to "western" herbs and the major companies that have been selling them for decades. Asian/Indian herbs and their production have always been manufactured and processed under a far lesser standard of quality then North America or Europe as a whole.
Not true historically - really that has been the case only since the early 20th Century. Quality control prior to that was essentially non-existent in the Western world. Fraud and toxic formulations were common. That is, in fact, why many of the regulatory laws were passed in North America and Europe.
Herbal medicines can also be powerful, toxic, harm certain populations due to risk factors, and can combine with other things (such as alcohol) to cause harm. There should be some regulation there.
Agreed. Of course everything depends on WHAT herb as well. Obviously Foxglove and Wolfsbane should not be sold promiscuously. We get Digitalis and Aconite from both respectively and they are extremely powerful and potentially dangerous.
Yes, and opium and morphine are also extremely close their their "herbal" states and are likewise quite problematic. The most powerful/dangerous herbal remedies have already been annexed by the medical-pharmaceutical professionals.
There is a general group of herbs that are now well known and at the very least minimally evidential and relatively benign to the best of our knowledge. This includes Garlic, Milk Thistle, De-Glycyrrhizinated Licorice, Bilberry, Grape Seed Extract, Ginko Biloba, etc. etc.
Garlic and ginko have both been linked to hazardous bleeding during surgery and traumatic injuries. Ginko slightly raises the risk of hemorrhagic strokes. You noted "de-glycyrrhizinated licorice" - that's not the "natural" state, it's significantly modified.
That's the entire crux of my point, and the other people in Canada who does not feel the government should have the right to retroactively re-classify these particular type of products as "investigational drugs".
In (if I recall the year correctly) 1914 the US government moved opium from over-the-counter to prescription only - how was that different?

It was when none of the authorities believed herbs were at all useful that they were entirely ignored. The desire to regulate is actually acknowledgment that these things have real effects on the human body.
I'm saying that the onus should be on the government to provide reasons to proscribe certain herbs based on evidence of toxicity or misuse.
The problem with that approach is that it usually means people die before satisfactory mechanisms are put into place. In other cases they are damaged, sometimes permanently.
So, medication error leads to death. If that's so, why not included cynaide poisoning from alternative treatments, including the infamous apricot laetrile?
Rare cases of individual products does not justify tarring all with the same brush. In your example it's not even an herb. It's an extraction from the pit of a fruit.
Digitalis is an extract from foxglove. Opium is an extract from poppies. And so on and so forth.
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Not true historically - really that has been the case only since the early 20th Century. Quality control prior to that was essentially non-existent in the Western world. Fraud and toxic formulations were common. That is, in fact, why many of the regulatory laws were passed in North America and Europe.
Well yes..but that's a fairly long time now wouldn't you say? Early twentieth centurn is now almost 100 years old. That's a pretty decent stretch of time. :P
Yes, and opium and morphine are also extremely close their their "herbal" states and are likewise quite problematic. The most powerful/dangerous herbal remedies have already been annexed by the medical-pharmaceutical professionals.
As well they should be. I would never argue that just because an herb was effective in it's natural state that it should be immune to regulation.
Garlic and ginko have both been linked to hazardous bleeding during surgery and traumatic injuries. Ginko slightly raises the risk of hemorrhagic strokes. You noted "de-glycyrrhizinated licorice" - that's not the "natural" state, it's significantly modified.
Yes because anyone in the know is aware that both garlic and Ginko thin the blood and do so quite effectively. In fact that's exactly the point that these two herbal products can do what Warfarin does with arguably less risk of toxicity or side effects. I'm sure the drug companies are THRILLED about that ability..
And yes, DGL licorice is with one specific component removed. The reason is the aldosterone effect which causes changes in people's blood pressure. I know you're very well aware of this. I say it only for the benefit of people reading the thread.
But this is again a good example of putting knowledge into action where it's warranted. These particular herbs are already treated with a greater respect and a list of warnings and contraindications. We do NOT need all herbs to be subject to pharmaceutical standards in order for this to be accomplished.
In (if I recall the year correctly) 1914 the US government moved opium from over-the-counter to prescription only - how was that different?
Because it's indentified quite accurately as a substance with serious potential for abuse. Because of euphoria for one. People will not swallow 60 capsules of milk thistle a day because they get a "high" from it. They take it based on efficacy. Obviously any herb with psychedelic properties, potential concerns with overdose in cases of Ephedra, etc. must be held to a different standard. No different then aspirin being held to a low standard of control as an over the counter drug compared to a very STRICT level of prescription Oxtcontin. Again, we do not need to create a black & white fallacy here. In cases where it is warranted, certain herbs should be lifted from the general market and deemed pharmaceutical property, or simply banned as too dangerous and/or ineffective. No argument here.
The problem with that approach is that it usually means people die before satisfactory mechanisms are put into place. In other cases they are damaged, sometimes permanently.
Come on Broomy! You know that's not the case with the normal lineup of the ones I'm referring to. Of course if they discover a new herb in the rain forest and some company picks it up and distributes it without any clue of it's general safety profile, especially long term, then you're begging for trouble.
I'm arguing the case for the great majority of herbs that in the last few decades in particular have demonstrated a reasonable postulation for efficacy and a seemingly benign toxicity in the main.
Lets look at this as things really are. Herbs have slipped through the cracks in many ways. Unlike investigational drugs, they have sometimes centuries worth of anectdotal testimony to their general effect on specific function or disease treatment and obviously a much lesser incidence of toxicity or side effects other then the obvious ones that have already been snapped up by the pharmaceutical companies in the early days.
Digitalis is an extract from foxglove. Opium is an extract from poppies. And so on and so forth.
Of course. Which again validates my point. Those are extracts. Modified isolates. They are no longer herbs in any event and may not even be useful in their "original" state, yet the other herbs I'm arguing for, DO demonstrate a safe and effective mechanism of action in their own right. At least enough to warrant them being available as a consumer's product.

In case you're somewhat playing devil's advocate here, can you spell out exactly how you think herbal products should be treated? Particularly in respect to ones like milk thistle, bilberry, Gingko...Would you support them being yanked from the shelves and no longer available OTC until and unless they pass a standard equal to pharmaceuticals or do you have a more moderate idea in mind?
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Justforfun000 wrote:
Not true historically - really that has been the case only since the early 20th Century. Quality control prior to that was essentially non-existent in the Western world. Fraud and toxic formulations were common. That is, in fact, why many of the regulatory laws were passed in North America and Europe.
Well yes..but that's a fairly long time now wouldn't you say? Early twentieth centurn is now almost 100 years old. That's a pretty decent stretch of time. :P
Long enough for people to forget how things used to be, and why those laws were passed in the first place.
Garlic and ginko have both been linked to hazardous bleeding during surgery and traumatic injuries. Ginko slightly raises the risk of hemorrhagic strokes. You noted "de-glycyrrhizinated licorice" - that's not the "natural" state, it's significantly modified.
Yes because anyone in the know is aware that both garlic and Ginko thin the blood and do so quite effectively. In fact that's exactly the point that these two herbal products can do what Warfarin does with arguably less risk of toxicity or side effects. I'm sure the drug companies are THRILLED about that ability.
The are also not as strong. There is the problem of people taking warfarin AND consuming ginko or garlic (or both).
And yes, DGL licorice is with one specific component removed. The reason is the aldosterone effect which causes changes in people's blood pressure. I know you're very well aware of this. I say it only for the benefit of people reading the thread.

But this is again a good example of putting knowledge into action where it's warranted. These particular herbs are already treated with a greater respect and a list of warnings and contraindications. We do NOT need all herbs to be subject to pharmaceutical standards in order for this to be accomplished.
The problem is the number of people who do not have this information.
In (if I recall the year correctly) 1914 the US government moved opium from over-the-counter to prescription only - how was that different?
Because it's indentified quite accurately as a substance with serious potential for abuse. Because of euphoria for one. People will not swallow 60 capsules of milk thistle a day because they get a "high" from it. They take it based on efficacy. Obviously any herb with psychedelic properties, potential concerns with overdose in cases of Ephedra, etc.
With ephedra the problem is NOT overdose - a normal, therapeutic dose can injure or kill a person with certain cardiovascular conditions. It does NOT take an overdose!
must be held to a different standard. No different then aspirin being held to a low standard of control as an over the counter drug compared to a very STRICT level of prescription Oxtcontin.
If asprin were up for review today as a new drug there is a strong possibility it would NOT be OTC. Between causing severe reactions in approximately 30% of asthmatics, blood-thinning issues, and the heightened risk of gastrointestinal ulcers it could well be seen as too risky. It enjoys OTC status due to the inertia of history.
The problem with that approach is that it usually means people die before satisfactory mechanisms are put into place. In other cases they are damaged, sometimes permanently.
Come on Broomy! You know that's not the case with the normal lineup of the ones I'm referring to. Of course if they discover a new herb in the rain forest and some company picks it up and distributes it without any clue of it's general safety profile, especially long term, then you're begging for trouble.
Ephedra has been used for millenia, it's hardly new, and yet people did (and sometimes still do) die from it's use.

I'll say more about the labeling issue down below.
I'm arguing the case for the great majority of herbs that in the last few decades in particular have demonstrated a reasonable postulation for efficacy and a seemingly benign toxicity in the main
.
Where is the proof of this efficacy with minimal toxicity?

If people can raise millions for a no-kill animal shelter or other charity why can't someone set up a foundation for really testing these remedies?
Lets look at this as things really are. Herbs have slipped through the cracks in many ways. Unlike investigational drugs, they have sometimes centuries worth of anectdotal testimony
Anecdote != data.
... to their general effect on specific function or disease treatment and obviously a much lesser incidence of toxicity or side effects other then the obvious ones that have already been snapped up by the pharmaceutical companies in the early days.
Digitalis is an extract from foxglove. Opium is an extract from poppies. And so on and so forth.
Of course. Which again validates my point. Those are extracts. Modified isolates. They are no longer herbs in any event and may not even be useful in their "original" state, yet the other herbs I'm arguing for, DO demonstrate a safe and effective mechanism of action in their own right. At least enough to warrant them being available as a consumer's product.
"Opium" is NOT a "modified isolate". Here's how you get opium:

1) Wait for post-flower seed pod to form
2) Score seed pod with sharp knife
3) Let the gooey stuff ooze out
4) Scrape gooey stuff off pod

That gooey stuff? THAT's opium. That's the stuff that people smoked or ate for millennia. Or they mixed it with alcohol to make it less gooey. I think there's more steps to making coffee or chocolate than that.

Digitalis, likewise, does not take much refining. That's why it, too, has been used for millennia (with recognition that's it's dangerous). Refining mainly consists of getting a consistent purity of active ingredient in order tightly control the dose for consistent effect, not in greatly altering what is already there.

Digitalis and most of the opiate family (there are a couple exceptions) are all off-patent, yet there is still a profitable market for them.
In case you're somewhat playing devil's advocate here
Ah, you caught me! :twisted:
...can you spell out exactly how you think herbal products should be treated? Particularly in respect to ones like milk thistle, bilberry, Gingko...Would you support them being yanked from the shelves and no longer available OTC until and unless they pass a standard equal to pharmaceuticals or do you have a more moderate idea in mind?

In an ideal world (ha!) I would like to see an intermediate level between MD/pharmaceutical level and the wild, wild west of wide open consumerism/selling. A person desiring herbal treatment would see someone knowledgeable for a discussion of desired effects, contraindications, and possible side effects. Perhaps there would be a foundation of some sort conducting real investigations into traditional/herbal cures so all concerned can have good, solid information. In said ideal world people would also go to a doctor for diagnosis, and doctors would be open to using such therapies.

One MAJOR problem is knowledge dissemination. Kava kava's problem with alcohol has been, as I said, well known in its place of origin - that knowledge did NOT reach the western world along with the root. Why not? Many people do not know about DGL licorice. Sassafras - which I happen to like - has been pulled from shelves because of concerns of liver toxicity but there is NOT ONE documented case of liver damage in a person due o sassafras consumption. There is a huge void of SOLID knowledge. The manufacturers are hamstrung here in the US - they have to very carefully word their information and that means stuff the consumer should know either can be or must be omitted from labels.

Too many people still think natural = harmless. In any dose.

On top of that, people are sue-happy (at least in this country). Some goof might be warned over and over "don't mix kava kava with alcohol", goes ahead and does so anyway, gets hurt.... and sues everybody in sight for their own stupidity.

ANYONE can sell herbal remedies - there is no way to know if the person behind the counter knows what the fuck he or she is talking about. Doctors would trust these things more if there was some sort of mandated education/certification process for the sellers. It's not the doctors are philosophically opposed to non-pharmaceutical cures or adjuncts - on two occasions in my life I have had MD's "prescribe" dietary changes as part of recovery from serious illness.

Which gets to another issue - the general public are fucking morons. Think about diabetes - for many people with Type II a change in diet can be the most effective medicine ... yet they don't do it. It can be done - my husband reduced the amount of medication he takes in half by changing his eating habits and losing 30 pounds. The average idiot wants a miracle cure that lets him go back to his bad habits, and if the pills aren't doing it, well, take more of them.

You see, the laws aren't written for the intelligent people - they're written to protect the morons. The people who won't do their own research, who if they google something utterly lack the capacity to sift through the resulting information in a rational manner.

I would like to see a world where something like ephedra can be on a shelf labeled "Effective for...." and "WARNING - DO NOT TAKE IF...." and people would fucking read the labels! But I don't think that's going to happen.
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Post by PainRack »

Justforfun000 wrote: I was referring more to "western" herbs and the major companies that have been selling them for decades. Asian/Indian herbs and their production have always been manufactured and processed under a far lesser standard of quality then North America or Europe as a whole.
Except that TCM and Indian medicines are traditional medicines which have even longer histories of usuage than European medicines. Thus, using your argument, they SHOULD be safer.

They're not.

Furthermore, if you wish to discuss about European "herbs", remember my previous example arsenic? I also recall reading about how some herbs are contraindicated for people with certain cardiac conditions.
It's these ones that people are concerned about and I do not think it would be fair to pass a bill like C-51, remove ALL of these from the shelves until 'someone' puts them through the drug trials, and ban consumers from purchasing or possessing these until they become approved. That's the entire crux of my point, and the other people in Canada who does not feel the government should have the right to retroactively re-classify these particular type of products as "investigational drugs".
The law in question is stating that you CAN"T make thereauptic claims, can't sell them as thereauptic devices unless the research is there. There's absolutely nothing to prevent you from just OWNING them. Look at Henna and Hemp shampoo.
It's specifically attributed to herbs alone and that's why I was looking for evidence explaining why herbalists feel that they ARE unique and not as simple as drugs.
And for the last time, stop attributing something special. Herbs are still chemicals.
No I don't believe that that's correct. The size of the dose does not seem to have a direct correlation to harmful potential. For example the effects of licorice as a canker sore treatment, (brand new study just out today in the news), shows great efficacy with no serious sides.
Serious, fucking distortion of the science. What your article is saying that a fixed, regulated dose of licorce extract works to soothe canker sores. (Whoopee doo. Here's a new hint. Try honey. It works well too. Although my current remedy is Wu Bi Gao, a mixture of the above and various stuff)

Nowhere in that article does it state that herbs have NO TOXIC DOSE. If you wish to discuss the science, the issue would be the gap between the thereauptic range and the toxic range. Vitamin A and Paracetemol is a perfect example of this. The gap between thereauptic range and toxicity is extremely wide.

Now do you get the point?
Ma Huang is an herb that needs a bit more caution. It is weaker then Ephedrine as an isolate, true, but it is an herb that leans a bit more towards the drug side in comparison of action, especially with symptomatic relief of congestion.
Based on WHAT FUCKING SCIENCE? The reason why Ma Huang works is because it has various active ingredients, the most active being an alkaloid named ephedra.
Obviously I'm not trying to suggest all herbs should be exempt from scrutiny.
No. You're trying to suggest that herbs are a special group, not subject to chemistry and physical laws simply because they're herbs.
Get it through your head. They're CHEMICALS. No different from drugs.

We don't need to create a false dilemma here where we choose between all herbs being regulated as drugs or none of them being controlled whatsoever.
Why not? They're CHEMICALS. Definition of drugs= Chemical which cause a chemical action in the body. Medicine(or medical drug)= Used to cause a thereauptic action.

Why on god green earth are you attempting to insert a blatently false barrier?
I'm saying that the onus should be on the government to provide reasons to proscribe certain herbs based on evidence of toxicity or misuse. I don't believe the default should be on someone in the industry to prove the herb is safe and pharmaceutically as effective as a drug through millions of investment dollars that they will NOT be able to patent for themselves.
And the Bush adminstration failure in war, environmentalism, family planning and every single major domestic policy hasn't told you how stupid this approach can be?
Do you even know that this was the EXACT, SAME, FUCKING excuse the drug industry pulled back in the 19th century? You're refighting a dead and buried battle.
Yes! They are an entire plant and sometimes food is our medicine.
And? Vitamin A has a toxic range. Its fat soluble. Vitamin C doesn't, but the only reason it doesn't is because its water soluble and thus, any excess is excreted through the kidney easily(Which would beg the question of what happens when an ESRF patient takes huge doses of Vitamin C)

Do you even know that food itself has side effects and toxic effects? Seal blubber and liver(Or is that polar bear?) is the perfect example of this.

For side effects, look at something called indigestion and flatulence. Similarly, diet itself can worsen certain conditions. For example, caffeine itself will cause gastric ulcers. Thus, a person taking caffeine to help protect against liver failure will run the risk of gastric ulcers. Oops.
Milk is another example. A person with colic pain is advised not to take dairy products, cause it cause increased cramp pain.

Adverse reaction? Allergic reaction, or lactose intolerance. Dairy is the most common, but there's also G6PD.

Welcome to the world of science. Stop trying to treat herbs as if they're aren't chemicals.
Herbalists suggest for most diseases, there is an herb and while we may not have every single thing lined up for all conditions, they have been fairly accurate at finding something to aid most human conditions. There is no doubt that the planty world has many things to offer us in treating our bodies and their disorders. One would almost think it was 'designed' this way to have a growing pharmacopeia in the world to meet our needs.
And since a good majority of our pharmateciual arsenal comes from plants and the natural world, how on earth is this DIFFERENT?

Again, what are their special chemical actions that they can somehow skip ALL the chemical issues? Let's try something.

Hypertension. Why would herbs have no side effects? Are you attempting to claim that hypotension would NOT be a possible side effect, even though this is its EXACT ACTION?
Are you attempting to claim that nature is so precise that the exact receptors which cause the desired reaction exists ONLY at the target site and the target site only?

As I've said before, herbalists profess that herbs as a whole have a method of action that is more comprehensive and demonstrably less inclined to side effects when used as an entire product with the active ingredients located and standardized, (like Milk thistle at 80% Silymarin, calculated as Silybin), compared to isolating and extracting the prime ingredient they believe is mainly the active principle. Supposedly previous attempts to do this has demonstrated exactly that. Some degree of action, but a much higher incidence of side effects and no suggestion of an adaptogenic property any longer that would temper it's action in the human body based on your needs.
Tell you what. Show the science then.

This is utter and total bullshit. You're trying to suggest that herbs are so specially tailored that the exact same receptors on other target sites would not be affected, and only the desired target site would be. TO make things even more funny, you claim that dosage isn't a major issue and toxicity/adverse reaction isn't a major problem, suggesting that somehow, the target receptor/cell knows exactly how much chemicals to absorb and uptake , violating the mathematics of diffusion and concentrations. Not to mention different bodies metabolism and conditions.
But this does not mean that our current dictionary classification is CORRECT. It is probably incomplete because to start with, almost anything can fall under the category of a drug when taking the simple definition of Merriam's Dicitonary : (3): a substance other than food intended to affect the structure or function of the body.
Geez. Guess what. THAT IS THE DEFINITION OF A DRUG.

That's why sniffing glue is considered drug abuse, or substance abuse depending on legalase. However, its STILL drug dependence and undergoes basic chemical reactions.
Other's have more specific definitions, but that is one of them listed above and it is VERY broad.
Please don't pull an idiot on us and try rewriting dictionary definitions.


But the point here is in many cases the "HOW" is already done for you. Herbs are grown into a useful combination by virtue of their nature. However to be fair sometimes you DO need to remove some other constituents....Ricin from Castor Oil is one thing that comes to mind..
This is NOT a creationist forum. You're simply suggesting that taking 85% of junk and 15% of desired material is better than taking 50% of active material and 50% of holding/junk material.
The argument may not be any different, but the fact remains that they CAN patent their drug product once trials are complete and this is not the same for natural products.
And we been through this before. The products itself can be patented, just not the basic material. That is no basic problem in and as of itself. Aspirin if anything shows how this is a nonsensical argument, even if we don't venture into the beauty industry.
With no clear evidence on what or who was responsible, I'd hardly say this was a convincing anectdote. Especially since some feels he mau have been deliberately killed.
Right. So, a conspiracy theory is infinitely more palpatable than the fact that TCM has been shown to have high levels of mercury in it? Are you fucking insane?

Let's compare the facts shall we?
We know that TCM have toxic levels of mercury, because we're faced and licked that problem in the nineties(Well, if you're not in China). Huo Yuanjia was taking doses of TCMs that is historically known to have high levels of mercury.
His symptoms match that of mercury poisoning.

What's next? Hitler survived and is hiding 10,000 leagues underneath the North Pole?
Because the drugs have MUCH more likelihood of side effects. Many herbs taken to lower cholesterol like Garlic, do not have anywhere NEAR the sides commonly found in drugs like Lipitor. Same with taking celery salt for high blood pressure. Observe:
Let's ignore other potential actions and take it on its face value.(Fibre itself is known for reducing cholesterol and BP).

Whos to say if you don't OVERDOSE on the chemicals you won't get the same side effects of anti-hypertensives? Hypotension? Who's to say that you won't need to titrate the dose once you make the action and dose more potent? And note. Its NOT THE WHOLE HERB. Its a SINGLE, ACTIVE, INGREDIENT.

So I'm not just saying that whole herbs are in many cases different because of the concept of adaptogenic capability, but overall in MOST cases are far more likely to be non-toxic even when used at a dosage that is clearly therapeutic. It may not be magic, but it's a wonder of nature.
Excuse me but I'm not impressed. I have a whole array of drugs in the medicine trolley that is therapeautic without being toxic. As for side effects, given that herbal remedies such as Senna, Glucosamine HAS SIDE EFFECTS, I believe its more that you're unaware of the potential side effects or more likely, the research and trials haven't been done yet. Which this new legislation will push manufacturers to do.

Oh wait. You forgot that Senna and Glucosamine, used by many to treat common conditions have side effects don't you? Infact, other than the risk of liver failure(an adverse reaction, not a side effect), Glucosamine has virtually the same side effects as conventional NSAIDs used to treat arthritic pain. The way of avoiding the side effects are different but its using conventional biochemistry, (glucosamine is changed to powder, NSAIDs are titrated and taken with an adjucant. Although I see no reason why Glucosamine can't be taken with the same adjucants, although albeit, maxalon is overkill to treat simple indigestion)
I canot answer this. I can only point out what others have discovered as conclusions, not the full mechanisms of action. But this is not much different then many drugs. They STILL do not fully understand how aspirin works and it's one of the most well-studied and commonly used drugs in existence today.
No one disputes that. However, no one claims that aspirin has some magical property that causes it to violate ALL OTHER CHEMISTRY AND PHYSICAL PROPERTIES!

Get that in your god damned SKULL. I'm NOT DISPUTING THE POTENTIAL EFFECTIVNESS. I'm disputing your specific claims that herbs are different, because they're NOT DRUGS. Its NONSENSE. They're BOTH CHEMICALS.
Well if I did I'm sorry, no they are not the ONLY things used for preventative, but they do tend towards a much larger percentage of that category then most pharmaceutical drugs.
Based only on your limited and twisted meaning of prophylaxis.
This is true, but the argument here is that all of these drugs tend to have unwanted sides and in many cases can be harmful albeit at an acceptable risk to benefit ratio, whereas many herbs are touted to be EQUALLY as effective sometimes, and yet far less likely to be harmful or rife in sides. This in many cases still needs to be proven absolutely, but most preliminary or intermediate studies seem to bear this out very well for most herbs.
Read above. Herbs are chemicals too.
I enjoy your points and you really do get me thinking a lot more in depth about this in any event. I've always admired your posts, so by all means if you still think I'm missing something, hammer away at me. Maybe you'll get me to change my mind, but so far I really do see this from the side of the people wanting to use herbs they feel are safe and effective without government interference causing a dramatic withdrawal of hundreds of products.
Freedom of choice is also used by smokers as an argument.


Furthermore, we're not disputing the potential effectiveness. No one here has. What I'm disputing is your nonsensical argument that herbs should be treated differently from drugs because somehow, they're not chemicals.
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Post by PainRack »

Justforfun000 wrote: Well yes..but that's a fairly long time now wouldn't you say? Early twentieth centurn is now almost 100 years old. That's a pretty decent stretch of time. :P
No. Nutritional supplements have been shown to have up to 50% variance in their stated dose of active ingredients..... Although I can't recall whether the tests were on "natural" or combined both "synethic and natural" based supplements.

Natural based supplements will invariably have a higher variance, based simply on biology.
Yes because anyone in the know is aware that both garlic and Ginko thin the blood and do so quite effectively. In fact that's exactly the point that these two herbal products can do what Warfarin does with arguably less risk of toxicity or side effects. I'm sure the drug companies are THRILLED about that ability..
Actually, they don't care. Garlic and Gingko hasn't been able to provide a consistent, titrated action to PT/PTT times yet as opposed to Warfarin. Furthermore, warfarin itself is "natural".
Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in licorice, lavender, and various other species

And let's not forget it has anti-fungicidal properties as coumarin too:D
People will not swallow 60 capsules of milk thistle a day because they get a "high" from it.
So? That's why we have something called OTC drugs.

Just to recheck since I obviously never read the act in its entirity. Does the act say that herbal medicines can only be prescribed by doctors?
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Post by Justforfun000 »

Ok I'll have to somewhat concede the argument for now (in relation to Painrack) as I'm just not qualified enough to argue any further from the herbalists point of view. I could still argue some particular points you raised, but the ultimate argument comes down to the chemical relationship between herbs and the body in comparison to drugs and the body and you are saying quite clearly that there is no true difference and you don't feel that the 'adaptogenic' nature of herbs has been proven whatsoever. I don't know where to look to argue in any further depth...so

I'll assume your points in relation to the chemistry of herbs and their relationship to side effects are possibly accurate, but if this is so, I don't see how the herbalists and councils like the Canadian Health Food Association can possibly be aware of all of these points you're making and still stand by their assertions that most herbs are generally 1) safe, 2) effective and 3) in a truly different category of pharmaceutical consideration then drugs. That would make their stance a little ethically questionable...

All in all I agree with Broomstick's outline for how they would be treated in an ideal world. As it is, here is a breakdown of the proposed bill and it's effects. I think they're far too restrictive:
Bill C-51 Will:
Allow Government agents to:
-Enter private property without a warrant Section 23 (4)
-Confiscate your property at their discretion, at your cost Section 23.3 a
-Dispose of your property at their discretion, at your cost Section 23.3 c
-Seize your bank accounts without a warrant Section 23 (2) (d)
-Charge you for shipping and storage of your property Section 23.3a-b
-Store your property Indefinitely without paying you for damages Section 23 (2) (d)
-Levy fines of up to $5,000,000.00 / 2 years in jail per offence. Section 31.1

Introduce new legislation that will:
-Allow laws to be created in Canada, behind closed doors, with the assistance of foreign governments, industrial and trade organizations Section 30.7
-Allow "Crack house style" of enforcement on natural health providers Section 23.1
-Allow enforcement to be considered on more than 70% of Canadians who use NHP's Health Canada Reference
-Allow the minister, based on opinion, to shut down research without any scientific reason or evidence of risk or harm Section 18.5
-Allow the minister, based on opinion, to allow or disallow market authorizations for Natural Health Products
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Post by PainRack »

Justforfun000 wrote:Ok I'll have to somewhat concede the argument for now (in relation to Painrack) as I'm just not qualified enough to argue any further from the herbalists point of view. I could still argue some particular points you raised, but the ultimate argument comes down to the chemical relationship between herbs and the body in comparison to drugs and the body and you are saying quite clearly that there is no true difference and you don't feel that the 'adaptogenic' nature of herbs has been proven whatsoever. I don't know where to look to argue in any further depth...so
I'm not claiming that no such nature exist. I don't have the learning for it. I'm merely contesting your point that somehow, herbs are "special" from drugs just purely because. Again, both of them are nothing more than chemicals. The rest of your points must firmly ground that in mind. Herbs have no supernatural effect. They can and will be studied with the same scientific tools and benchmarks we used to investigate previous drugs and acquire new medicines.

I would also like to point out that if naturalists had merely kept better documentation and history instead of focusing on OTC sales and unregulated health clinics, researchers looking for the good stuff would had a much easier time. Claims of focusing on healing, not paperwork is nonsensical. How on earth do you know your client is getting better if you DON"T have the paperwork for it?
I'll assume your points in relation to the chemistry of herbs and their relationship to side effects are possibly accurate, but if this is so, I don't see how the herbalists and councils like the Canadian Health Food Association can possibly be aware of all of these points you're making and still stand by their assertions that most herbs are generally 1) safe, 2) effective and 3) in a truly different category of pharmaceutical consideration then drugs. That would make their stance a little ethically questionable...
I would contend that the news articles are "misleading". Its the same way how news articles misrepresent scientific discoveries and the like, look at the way chocolates and wine is hailed as the "save your heart" foods.
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Post by Justforfun000 »

I'm not claiming that no such nature exist. I don't have the learning for it. I'm merely contesting your point that somehow, herbs are "special" from drugs just purely because. Again, both of them are nothing more than chemicals. The rest of your points must firmly ground that in mind. Herbs have no supernatural effect. They can and will be studied with the same scientific tools and benchmarks we used to investigate previous drugs and acquire new medicines.
K. Fair enough. I guess what's really needed is some firm evidence showing this 'adaptogenic' quality that might separate herbs from drugs because of the full chemical makeup of the plant and it's (by herbalists) touted ability to act "smartly" in many cases and only have an effect when needed. See they claim that certain herbs can help lower blood pressure, but if your blood pressure was already normal, it wouldn't. Whereas a drug will lower it no matter WHAT state it's in.

You have a good point though. This truly has to be proven before demanding herbs be treated as special exceptions to drugs. I was under the impression that it was already demonstrated convincingly enough, but maybe it's just been said so often as 'fact' by many publications and stories I've read that I took it for granted it came from reputable studies. It wouldn't be the first time that's happened to me.

Try to find the original studies saying 8 glasses of water a day are ideal. Many people take that as a nutritional gospel. Not long ago I found out it's a myth. One good thing about the internet..you can certainly get over inundated with information, and many times MIS-information, but go to the right places and you tend to find good debunking on many claims.
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Post by PainRack »

Justforfun000 wrote: K. Fair enough. I guess what's really needed is some firm evidence showing this 'adaptogenic' quality that might separate herbs from drugs because of the full chemical makeup of the plant and it's (by herbalists) touted ability to act "smartly" in many cases and only have an effect when needed. See they claim that certain herbs can help lower blood pressure, but if your blood pressure was already normal, it wouldn't. Whereas a drug will lower it no matter WHAT state it's in.
Those claims are plainly nonsensical. Let's put it this way, if such an ability exists, we should already have seen it in the human body or some other animal. We don't.
Try to find the original studies saying 8 glasses of water a day are ideal. Many people take that as a nutritional gospel. Not long ago I found out it's a myth. One good thing about the internet..you can certainly get over inundated with information, and many times MIS-information, but go to the right places and you tend to find good debunking on many claims.
There never was any facts saying 8 glasses of water a day is ideal. Its was just an off the cuff recommendation based on how much water a person needs to ingest, whether it was from liquids or foods.
Let him land on any Lyran world to taste firsthand the wrath of peace loving people thwarted by the myopic greed of a few miserly old farts- Katrina Steiner
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