OK, since I'm bored, I'm going to get into this one.
Baal, did you read Samuel's post? Past the first sentence, I mean. He said:
Civilians compose the Republic, and when they are all dead, it is no longer a problem. You don't have to kill that many though- just enough to case the war industries to collapse.
Ok, so, let's assume that somehow, killing all the Republics citizens won't cause it to collapse (Highly unlikely, see Japan in WW2, it was in the same situation (a lack of resouces) but for a different reason. As we all know, Japan
lost the war because of this). The mere fact that the CIS were able to kill that many people implies that they are able to face the Republic on equal footing, as the CIS had to have done it somehow, and (whether it's a superweapon or sheer numbers) if the CIS can kill civilians using these methods, they can probably kill the GAR with the same method. Note that starships rule out bioweapons to use on the GAR because they are able to traverse space (meaning they are sealed off).
Another problem with your argument, which I disregarded in the scenario above, is the fact that if you kill the civilians, there is no-one to work in the factories. I'm sure that even you could follow this one through, but you're probably thinking "What about droids? They can work the factories instead!". The answer to this one is extremely simple: the Republic is fighting a
droid army, so I'd actually be surprised if droids were still working in war factories!
I think that's all your points addressed, but feel free to correct me on that if it isn't.
Ok, and since you've responded to someone else's statement, I'll answer that one in a few words: What. The. Fuck. How is Palpatine's plan relevant to his point? In fact, it disproves the 300 nonsence right off for two blindingly simple reasons:
1) You'd need a shitton of clones to take down all the Jedi, even with the element of surprise.
2) To get said element of surprise, you'd need to convince said Jedi that there was a massive war going on, which is much easier and can be done more efficiently if you actually make said war happen!