The Gift of Life, and Its Price discusses IVF, in vitro fertilization, and some of the consequences both good (babies!) and bad (sick babies!).
Some background not covered - I remember the birth of the first IVF baby, Louise Brown. Not the singular "baby". These days, more and more IVF births are twins. As 60% of twins are born premature the mere fact of being a twin carries some risk. Now, clearly, not all twins have a problem. "Premature" might mean a week early, and many twins suffer no problems from sharing a womb. On the other hand "premature" can mean months early and yes, there can be serious consequences.
Some quotes from the article:
But an exploration of the fertility industry reveals that the success comes with a price. While IVF creates thousands of new families a year, an increasing number of the newborns are twins, and they carry special risks often overlooked in the desire to produce babies.
While most twins go home without serious complications, government statistics show that 60 percent of them are born prematurely. That increases their chances of death in the first few days of life, as well as other problems including mental retardation, eye and ear impairments and learning disabilities. And women carrying twins are at greater risk of pregnancy complications.
In fact, leaders of the fertility industry and government health officials say that twins are a risk that should be avoided in fertility treatments. But they also acknowledge that they have had difficulty curtailing the trend.
Many fertility doctors routinely ignore their industry’s own guidelines, which encourage the use of single embryos during the in-vitro fertilization procedure, according to interviews and industry data. Some doctors say that powerful financial incentives hold sway in a competitive marketplace. Placing extra embryos in a woman’s womb increases the chances that one will take. The resulting babies and word of mouth can be the best way of luring new business.
Doctors are also often under pressure from patients eager for children, who have incentives to gamble as well. Frequently, they have come to IVF as a last resort after years of other treatments, are paying out of pocket, and are anxious to be successful on the first try. And many do not fully understand the risks.
The industry creates preterm infants with in-vitro and other fertility treatments even as government and nonprofit groups work to fight the nation’s 12.7 percent rate of prematurity, regarded as a major national health care problem.
While IVF multiples are typically the children of affluent women, much of the effort at reducing premature birth has been focused on prevention and prenatal care for low-income women. A study released last week by the March of Dimes cited fertility treatments as one of the main reasons for a 36 percent increase in prematurity in the last 25 years.
The government estimates that caring for premature infants costs $26 billion a year, including $1 billion for IVF babies, expenses that eventually get passed through the system and on to businesses and consumers.
The two medical organizations and the federal Centers for Disease Control and Prevention have been promoting the use of single embryos in many cases to reduce the number of twins. But that has not translated into major action at the 483 fertility clinics across the country. The latest figures from the industry show that women under 35, the group most likely to get pregnant from the treatments, choose to use single embryos in only 4.5 percent of in-vitro rounds.
“You can’t convince a couple that having twins is a bad thing,” said Dr. Maurizio Macaluso, who runs the C.D.C.’s women’s health and fertility branch. “That’s a major communication problem.”
Ms. Mastera’s insurance would cover about $8,000 for the procedure and drugs. Frequently, insurance does not cover anything. Almost $18,000 in clinic fees and other costs remained for the couple, who proceeded to cash out their 401(k) and money market accounts and put the remaining balance on a low-interest credit card.
Like many families, the Masteras could not afford a second cycle. So when the couple was given a choice by their doctor of implanting one or two embryos, they decided to increase their chances with two.
“This was our Hail Mary pass,” said Ms. Mastera, now 33. “We thought, let’s just do it. At the time, it was like, twins, they can be fun. They are fun, but holy cow.”
Some public health experts are frustrated by the disconnect between the medical risk of twins and society’s perception.
Dr. Alan R. Fleischman of the March of Dimes, which has begun distributing literature discussing single embryo transfer, said a result of playing down the risks of multiple births is that many women undergoing in-vitro prefer to have twins.
“It’s not just a matter of hoping that if you put two embryos in, you’ll get one baby,” Dr. Fleischman said. “There are many women who actually want to have two children and would like to have their full family with one pregnancy.”
Now, of course, twins will happen no matter what. Even if a single embryo is transferred there is the possibility of it splitting to wind up with two babies (even three - identical triplets have occurred). And I am all in favor of doing what we can to have healthy outcomes for twins and premature babies. There are many people who were born premature and went on to have healthy, productive lives - including my eldest surviving sister, who was born two months premature but not only produce two lovely children of her own and is a highly intelligent human being, but is now a doctor who unquestionably provide benefit to society. Her prematurity apparently has had no lasting ill effects. However, it is one thing to manage the outcomes of nature and chance, quite another to be manufacturing twin births.In March, the United States Chamber of Commerce and the March of Dimes held a luncheon in Washington to discuss preterm babies. “The human costs are staggering,” Dr. Steven K. Galson, then the acting surgeon general, told the group. “The medical costs are staggering. That’s why we’re here.”
“Today you’re going to hear that preterm birth is not just a significant public health issue,” Dr. Galson said, “but that it also impacts businesses and employer health plans.”
The hospitalization and doctor’s care for Ms. Hare and her son exceeded $1 million. Most of that, about $750,000 to $800,000, was for Carter. The bill was picked up by the self-funded health plan of the Trammell Crow Company, the Dallas real estate investment company where Ms. Hare worked.
“The following quarter during the earnings release, somebody asked why there was a sharp increase in medical costs,” Ms. Hare said. No one identified her, but Ms. Hare knew that her family had contributed heavily.
In Atlanta, the Centers for Disease Control and Prevention hired an economist to predict what would happen if single embryo transfer were used in a large number of IVF cases.
Dr. Macaluso, the C.D.C. reproductive health official, estimates the patients, businesses and insurance providers would save more than $500 million annually, even taking into consideration the cost of extra in-vitro rounds, by lowering neonatal intensive care, special education and other costs of premature babies.
To reduce the number of twins, some clinics are experimenting with programs that provide IVF with single embryo transfer with free freezing of extra embryos and free transfer of frozen embryos if the first try does not work. Others are working to develop ways to identify the specific characteristics of a single embryo that will turn into a healthy baby.
Of course, the is a multi-factorial problem. It is entirely human to want babies. Evolution has selected for the desire to reproduce. Society only emphasizes that drive by social rewards given to parents, which is often increased for the "super fertile" (whether they are that way naturally or artificially). Doctors at fertility clinics do want to stay in business and make money, of course, but that is not incompatible with a sincere desire to help couples have babies.
So... what is the solution? Greater regulation? Greater education as to the risks involved? What?