Major animal disease (Rinderpest) eradicated

[Guardsman Bass]

Rinderpest was an ancient disease responsible for some rather devastating die-backs in cattle herds over the centuries. Apparently it is now eradicated:

Rinderpest, a cattle disease that for centuries felled herds in Europe, Africa and Asia and caused periodic human famine, has been eradicated, veterinary epidemiologists announced this week.

Eradication is the Holy Grail of disease prevention and has been successful only once before. Smallpox, an equally devastating human scourge, was eradicated in 1980, proving it is possible to stamp out a microbe across the entire planet. Attempts are underway to rid the world of polio and Guinea worm disease.

The bovine equivalent of measles, rinderpest is described in ancient Chinese writings and in documents from the Roman Empire. It hobbled Charlemagne when he moved herds to support his armies in the 8th century. When it entered Ethi­o­pia in 1889, it caused starvation that killed one-third of the country’s human population, even though the microbe does not infect people.

Even in communities that do not depend on herding for their livelihood, rinderpest could be lethal because it killed draft animals and disrupted agriculture.

“This is quite a momentous occasion for humanity,” said Juan Lubroth, chief veterinary officer of the U.N. Food and Agriculture Organization (FAO), which next month at its headquarters in Rome will officially declare the disease eradicated.

William R. White, a rinderpest expert at the U.S. Department of Agriculture, said: “The suffering that this disease has caused through the millennia is incredible. This is probably the greatest achievement in veterinary medicine.”

Rinderpest, which means “cattle plague” in German, is highly contagious and has a fatality rate of about 80 percent. It is the only animal disease to have been eradicated; smallpox occurs only in human beings.

Clean bill of health

The World Organization for Animal Health, at its annual meeting in Paris on Wednesday, accepted documentation from the last 14 countries that they were now free of rinderpest. The organization, which goes by its French acronym, OIE, was started in 1924 in response to a rinderpest importation in Europe.

The most recent recorded outbreak occurred in Kenya in 2001. Much of the past decade has been spent looking for new cases, in domesticated animals and in the wild, wandering herds of ungulates, or hoofed animals, in East Africa. The last place of especially intense surveillance was Somalia, where the final outbreak of smallpox occurred in 1977.

“There are a huge number of unsung heroes in lots of countries that made this possible,” said Michael Baron, a rinderpest virologist at the Institute for Animal Health in Surrey, England. “In most places, they were ordinary veterinary workers who were doing the vaccination, the surveillance, the teaching.”

Ridding the world of other infectious diseases, however, has proved even more difficult.

Smallpox eradication took 11 years of intensive effort and was aided by a hard-to-miss rash that made finding cases easy. The effort to eradicate polio, launched in 1988, has proved far more arduous. It is now 11 years past its original deadline, with the virus — which in most cases causes no obvious symptoms — still circulating in eight countries. An effort to eradicate malaria failed spectacularly in the 1950s.

Guinea worm disease, a waterborne disease caused by a parasite, is the next likely eradication success. Last year about 1,800 cases were recorded in four African countries, down from 3.5 million cases worldwide in 1986.

Three things made rinderpest eradicable. Animals that survived infection became immune for life. A vaccine developed in the 1960s by Walter Plowright, an English scientist who died last year at 86, provided equally good immunity. And even though the virus could infect wild animals, it did not have a reservoir of host animals capable of carrying it for prolonged periods without becoming ill.

Eradication program

In 1994, the FAO launched an eradication program that was largely financed by European countries, although the United States, which never had rinderpest, also contributed money. The effort consisted of massive vaccination campaigns, which were made more practicable when two American researchers made a version of the Plowright vaccine that required no refrigeration.

Vaccination was accompanied by surveillance for the disease. One way that was done was with a technique called “participatory epidemiology” in which outside surveyors meet with herdsmen and ask open-ended questions about the health of their animals and when they last noticed certain symptoms.

“It was local knowledge that really helped us trace back the last places where transmission occurred — sitting down underneath a tree in the shade, listening to storytelling,” said Lubroth, of the FAO.

Blood samples were also routinely collected from herds to determine the extent of immunity. In some cases, wild animals were darted and tested to see whether they also had antibodies to the virus. No wild herds were vaccinated. However, it appears that the presence of the virus in wild animals required its presence in domesticated ones.

“If cattle are not a source of infection, then the virus in the other species naturally disappears,” said Bernard Vallat, a veterinarian who is director general of the OIE.

Rinderpest appears to have emerged in Asia. In Europe it was sometimes called “steppe murrain,” or cattle disease from the steppes. It was never endemic in the Americas. An importation to Brazil in 1921 was contained, as was one to Australia a few years later.

The vaccine consists of an extremely weakened form of the rinderpest virus. While it has never been known to cause disease, its use has been stopped to prevent the chance that it might “revert to pathogenicity” and cause the disease it is trying to prevent.

Baron, the English virologist and consultant to the OIE, said rinderpest eradication had one obvious thing that made it easier than eradication campaigns against human diseases.

“When it came to vaccination, the cows never had a choice,” he said. “But people have a choice.”

[Lord of the Abyss]

Excellent. It's good to see something so destructive eliminated once and for all.

[CJvR]

Good, Rinderpest burn in hell.

“When it came to vaccination, the cows never had a choice,” he said. “But people have a choice.”

IIRC Polio was essentially on the ropes when some stinking Mullahs in Africa convinced the locals that vaccination was an evil western imperialist conspiracy.

[Iroscato]

Good, Rinderpest burn in hell.

“When it came to vaccination, the cows never had a choice,” he said. “But people have a choice.”

IIRC Polio was essentially on the ropes when some stinking Mullahs in Africa convinced the locals that vaccination was an evil western imperialist conspiracy.

I heard that too, I believe we came extremely close to getting rid of it. Still, we'll get there one day. Then we'll invade a planet after thousands of years of no disease, and get wiped out by the native bacteria.

[Duckie]

I heard it was lack of proper vaccination in rural areas of south asia mostly, but I might be confusing diseases

[Iroscato]

It's the same with HIV and AIDS, we could be much further along in eradicating it, if it weren't for some stupid superstitions about vaccinations or treatments. A lack of education and too much mysticism is mostly to blame.
Who was that dickhead in Africa, who was a country's health minister, and said it was OK that he had slept with a woman who HIV-positive, because he had showered afterwards? Can anyone tell me?

[Duckie]

Actually in the south asia case it's mostly infrastructure and education, but don't let that get in the way of a good rage

[Broomstick]

Good, Rinderpest burn in hell.

“When it came to vaccination, the cows never had a choice,” he said. “But people have a choice.”

IIRC Polio was essentially on the ropes when some stinking Mullahs in Africa convinced the locals that vaccination was an evil western imperialist conspiracy.

I heard that too, I believe we came extremely close to getting rid of it. Still, we'll get there one day. Then we'll invade a planet after thousands of years of no disease, and get wiped out by the native bacteria.

Polio was beaten back to just one corner of one country (Nigeria) and then we got Religious Stupidity involved. Now it's expanded back to several nations. Nice going, assholes.

[Guardsman Bass]

I heard it was lack of proper vaccination in rural areas of south asia mostly, but I might be confusing diseases

There were and are some cases in India and Pakistan, but they're down pretty low now (they've fixed some of the implementation issues in rural areas). Nigeria's number of cases are significantly down as well (stupid "vaccines are a western imperialist plot to sterilize muslim children" nonsense in northern Nigeria was mainly a problem in the early 2000s), but there seem to be cases scattered all over sub-Saharan Africa.

The article has some interesting tidbits about other vaccination efforts, including a major anti-malaria push that failed in the 1950s and 1960s (there's some information about that here).

[Justforfun000]

Who was that dickhead in Africa, who was a country's health minister, and said it was OK that he had slept with a woman who HIV-positive, because he had showered afterwards? Can anyone tell me?

If I remember correctly.. Mbeki. But I didn't think he was the health minister..I thought he had a more prominent position..I should just google I suppose.

[Justforfun000]

Ah yes....Thabo Mbeki..he was actually PRESIDENT. here's an interesting factoid. imagine having this on your conscience:

"The Aids policies of the former South African president Thabo Mbeki's government were directly responsible for the avoidable deaths of more than a third of a million people in the country, according to research by Harvard university."

[Iroscato]

Actually in the south asia case it's mostly infrastructure and education, but don't let that get in the way of a good rage

I won't thanks.