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One ISD has appeared in the Alpha Quadrant. Let us conservatively assume that its general capabilities are roughly 60% better than the official specifications of an Acclamator transport, which gives it 400,000 light year operational range, 60% more light guns than an Acclamator, and 300 gigaton heavy guns.
Someone in the Q continuum has decided that it would be amusing to show the Federation that they have grown overconfident after defeating the Borg and the Dominion. He has altered the minds of the ISD's crew so that they believe that the Emperor has been killed along with Coruscant's entire population, thanks to a super-bioweapon secretly deployed by the Federation and its Alpha Quadrant allies in a cowardly first strike with no warning. The crew believes the Emperor sent them across spacetime with his dying will on a mission of vengeance, and they will fanatically carry out that mission, in an attempt to cause maximum casualties before they are taken down.
Question #2: if you were a Starfleet Admiral, what tactics might you try to use against this marauder? Is there any hope? Or is your only hope to bend over and kiss your ass goodbye? (EDIT: after Kaz's post, I thought I should modify the scenario so that this Q-nut briefs you on the capabilities and intentions of this vessel, so you're not totally in the dark).