"I won't let it happen again." Considering the plot of Deus Ex, he's in for a major disappointment.
So judging by the shot of Adam floating in the ocean amongst debris, not only is Human Revolution's "destroy Panchaea" ending apparently canon, but he apparently somehow survived it against all odds even though the ending gave every indication that he'd die along with everyone else there...I'm starting to think that Adam Jensen is one of those protagonists that's simply too cool/profitable to kill off, and that if Eidos ever gets tasked with remaking the original Deus Ex they'll find some way to retcon him into the game.
I've also seen some talk about there being random female enemies in the game. I hope that's true, as every single mook being male in Human Revolution was rather bizarre and downright offensive (I wonder if Belltower HQ has a big "No Girls Allowed" sign hanging over its main entrance, and if the Detroit Police Department only uses female cops to
pose as undercover prostitutes), especially coming after the highly gender-equal Invisible War (one of its few saving graces). Now if only they can also avoid any more distasteful bullshit like that asinine
developer bondage fantasy "Hyron Project" it should be golden.