I'd have to freshen up on the 2nd ed rules (not too hard, I like to fudge rules everyone now and again or improvize stats/events), and come up with a new adventure (or use one or two I've got lying around. One's pretty simplistic and my custom one is a bit rigid in its plot/setting), but other than that, I bet I could do a good job with a few people.
Hell, I ran a couple of adventures with Spanky before back in highschool, and he practically needed hand-holding each time. How hard could it be now?


EDIT: 1600th post. I win!