Just got this game on Friday. It coincided with me falling ill, so I've been playing it for a ridiculous amount of time while coughing, sneezing and generally feeling shit, so I might've missed some stuff.
I'm 28 hours in, right before the IFF mission on a derelict Reaper, done all loyalty quests except for Thane (probably won't bother, he's dying anyway. Though I liked his quip about how he found me

) and Samara (Jesus christ, can you get more nerd pandering than her
giant space tits my species totally aren't women and Miranda's I-might-as-well-be-naked-but-pretend-I'm-not outfit?).
FYI, I play a female sheppard, renegade+soldier, imported from ME1.
Some random observations:
- Dialogue is overall
much better than ME1, though it has some totally awkward and ridiculous moments. Whoever wrote romance with Jacob (I play a female Sheppard) was a total ass: I broke it up because of how
painful it was to listen to both the characters talk.
- The story is...hit and miss. The beginning is completely ridiculous, with a contrived "investigation" into Freedom's Progress colony and Cerberus rebuilding Shepard for...uh, for some reason. Because he's apparently a superweapon or something. Also, the Alliance is so mired in bureaucracy that there is
not a single marine present at a human settlement that disappeared into thin air days ago? That's beyond unbelievable, especially since in my playthrough, humans dominate galactic affairs. What, the Alliance can't spare ten guys to go and take a look/download security camera footage? For fuck's sake, the goddamn Quarians managed to realize one of their dudes on Pilgrimage was gone, and get a squad there!
On the other hand, the introduction of Garrus was just plain awesome, and there's dozens of little touches all around that are just brilliant.
- Mordin is a great character, and his sidequest is quite deep and compelling, exploring a difficult moral choice in a non-preachy way. The writing and voice acting is so much better than other loyalty quests it's not even a contest.
- It's kind of annoying that all loyalty quests are basically shooter missions with some dialogue in between: I kind of expected the Tali mission to be different, but no, it quicly got to "go shoot the geth".
- The Quarian "we spend our lives in enviro-suits" thing is getting ridiculous. Of course, it does neatly explain why they can't just settle any of the dozens of earthlike worlds you can discover during the game. Though with gene therapy commonplace and easy, I don't see why they need to bother and waste resources on building and maintaining the damn suits in the first place...
- The biggest thing: The game
works incredibly well. In fact, it runs better than ME1 ever did, while having graphics that are lightyears ahead (I turned off most of the postprocessing effects, though, because I hate them on principle). And I don't really have a great rig: PIV 3.4 HT/1024 DDR1/Radeon HD4650 with 1GIG VRAM, which is rather on edge when it comes the system requirements. Loading times are also never a problem: most animations can't even finish before a zone loads.
- I like the facial scars/terminator eyes far more than I thought I would. It makes Jacob's romance lines even more ridiculous, though. "I like what I see" indeed...
- The Paragon/Renegade thing is way better than in ME1, thank God. You're no longer a complete asshole to your crew if you chose Renegade, you're just a hardass commander with no time for wallowing bullshit. Of course, other times Renegade gets totally over the top (Punching a reporter in the face? What?

), or just plain ridiculous. I especially liked when you got +5 Paragon for threatening you'll break an Elcor's legs if he doesn't leave somebody alone. Truly, that's stuff heroes are made of!
Also, the scores themselves are schizoprenic. Letting missiles strike civilian areas: +5 Renegade. Saving a wounded Quarian from killing himself with dumbass heroics: +15 Paragon.
Man, those actions are, like, totally the same
- Why can't Garrus just put on his goddamn helmet when going into Omega's plague areas? His suit is still airtight after getting fucked up, as evidenced later on the Collector ship.
- Hard vacuum areas? Fear not, all a naked woman needs is an oxygen mask!
- Because it has to be said:
Bad woman:
Shepard! But...I thought you died!
Shepard:
I got better.
Works especially well if you have fully developed facial scarring. Man
Also:
Well, the Collectors killed you once, and all that did was piss you off.
Yeah, so it fellates the player and tells him what a badass he is. Call me vain.
- Normandy's crew is still furniture. Oh well.
- Endless MAKO driving is gone. Thank the Gods!
- OTOH, How come I've got key bindings for a ground vehicle in the menu, space in the cargo bay and EDI mentioning an embarked ground vehicle...and yet there's no ground vehicle present anywhere?