C. diff. - "This is the One We're Scared Of"

[Kanastrous]

Amy Warren had never heard of the germ that made her so miserable.

In January 2005, weeks after giving birth to her daughter, the Ohio mother of two knew only that she was in pain, suffering cramping so severe she felt like she was still in labor. Then came the diarrhea, uncontrollable bouts up to 50 times a day, which left Warren weak and raw and stranded in her Maineville home.

"I was so sick; I thought I had colon cancer and was dying," Warren recalled.

Three tests failed to detect the source of her intestinal trouble. A fourth, however, confirmed Warren as part of a toxic trend: She was among growing numbers of people sickened by an especially virulent form of the bacterial infection Clostridium difficile, known as C. diff.

Doctors told Warren she’d contracted the NAP1 type of the bacteria, a mutated version that produces roughly 20 times the toxins responsible for illnesses ranging from simple diarrhea to blood poisoning — and death.

“It’s like a science fiction disease,” said Warren, who struggled for six months through three relapses before controlling the infection. “That’s what scared me. People die from this.”

C. diff has long been a common, usually benign bug associated with simple, easily treated diarrhea in older patients in hospitals and nursing homes. About 3 percent of healthy adults harbor the bacteria with no problem. But overuse of antibiotics has allowed the germ to develop resistance in recent years, doctors said, creating the toxic new type that stumps traditional treatment.

"This is the one we're scared of," said Dr. Brian Koll, chief of infection control at Beth Israel Medical Center in New York.

C. diff produces anaerobic spores transmitted through feces that are able to survive for months on most surfaces. People are infected when they ingest the bacteria, typically by touching contaminated surfaces and then touching their mouths, or by eating contaminated food.

Overall infections caused by C. diff more than doubled between 2000 and 2005, according to the latest government figures. In 2005, the year of Warren’s illness, 301,200 cases of C. difficile-associated disease (CDAD) were logged in discharge records kept by the nation’s hospitals. Some 28,600 people who had the infection died.

That's only hospitals, however. Counting nursing homes and other care centers, the number of cases nationally is likely closer to 500,000, experts estimate.

Contaminated health care settings remain the main source of C. diff infections, primarily because they treat so many people with serious diarrheal illness. The NAP1 strain has been found in other sites and populations in recent years, infecting young adults and pregnant women with no history of antibiotic use, according to federal sources.

Despite the concern, scientists don't know how many people contract NAP1 infections, or how many die from them. C. diff infection is not a reportable condition in most states, although a rare pilot project that mandated reporting in Ohio in 2006 found more than 14,000 cases in hospitals and nursing homes that year, according to the state health department.

Mutant strain detected in 38 states

What is clear is that the most toxic strain is taking hold, according the federal Centers for Disease Control and Prevention.

In February 2007, 23 states told the CDC they'd seen cases of the NAP1 strain; by November, that number had grown to 38. Officials in the remaining states and territories contacted by msnbc.com said they hadn't detected the virulent bug, but most also said they don't look for it.

Better data about the scope of the C. diff problem may be available by this fall, when the Association for Professionals in Infection Control (APIC) presents the results of a prevalence study being conducted this month.

Last year, APIC was among the first agencies to note that rates of Methicillin-resistant Staphylococcus aureus, known as MRSA, were about 10 times previous estimates. The so-called superbug claimed headlines last year when researchers linked it to more than 94,000 infections and nearly 19,000 deaths in the U.S. in 2005.

Health officials now rank C. diff on par with MRSA as one of the top two infections acquired in hospitals.

“In light of how frequently it is already occurring as well as the trajectory of its recent increase, it is an infection that definitely deserves our respect and attention,” said Dr. L. Clifford McDonald, chief of prevention and response for a division of the CDC.

Attention must also be paid, scientists say, because the infection that mostly affects older, sicker people with long histories of antibiotic use now appears to be showing up in younger, healthier patients like Warren.

Warren’s not sure how she contracted the infection, which is caused when normal flora in the gut is disturbed, typically by antibiotics. About 90 percent of CDAD cases occur in patients who've used antibiotics recently, especially fluroquinolines such as the popular drug Cipro.

The resistance allows the C. diff bacteria to take over and flourish. Consequences can range from severe diarrhea to colitis and toxic megacolon, a condition that can lead to shock and death.

Amy Warren of Maineville, Ohio, smiled despite her illness in a 2005 photograph with her children, James and Celeste. Warren was 37 when she contracted a toxic strain of C. difficile after her baby's birth.

Warren, now 39, may have gotten the infection from her daughter, Celeste, who had a mild C. diff infection shortly after birth. Infants often harbor C. diff harmlessly in their intestines for about the first year of life, before more mature flora take over, experts said.

It's also possible Warren may have acquired the bacteria the previous fall, when she was briefly hospitalized and wound up sharing a room with a woman with severe diarrhea.

“I was sharing a bathroom with her,” Warren said.

‘Filthy’ hospitals perpetuate problem

There's no question that the rise of C. diff is tied to the cleanliness of the nation's hospitals, say researchers and health care advocates lobbying for better infection control.

"Outbreaks highlight the fact that standard infection control procedures in hospitals are not as good as they could be," said Dr. Curtis Donskey, director of infection control at the Louis Stokes Veterans Affairs Medical Center in Cleveland, Ohio.

Even after cleaning, studies show that C. diff spores linger on virtually every hospital surface, including bedrails, telephones, call buttons and toilets.

C. diff spores cling to patient skin, and not only in expected areas, such as the groin, according to a small-but-telling study published by Donskey and colleagues in the February issue of the journal Clinical Infectious Disease. Nearly 40 percent of patients diagnosed with CDAD infections tested positive for C. diff on their hands, and nearly 20 percent had the bacteria on their forearms, researchers found. About 60 percent had C. diff detected on their chest and abdomen.

Typical hospital germicides and alcohol hand sanitizers don’t kill C. diff, experts said. Instead, it takes bleach to eliminate it from surfaces and the friction of soap and water to remove it from hands.

But many hospitals have failed to make controlling C. diff a priority, critics contend.

“The biggest problem in our hospitals is that they are filthy dirty,” said Dr. Alfonso Torress-Cook, an epidemiologist who says he adopted practices that cut C. diff infections by 90 percent at his acute rehabilitation center in Orange County, Calif.

"If we start cleaning the environment, the infection will take care of itself," he added.

Interventions can range from ultra-violet light targeted to kill C. diff germs to silver-infused flooring and antimicrobial curtains aimed at resisting the bugs.

Making infection control a daily habit

The most important remedy is building infection control practices into the daily routine of organizations, said Koll, who is known for his work reducing potentially deadly central line-associated bloodstream infections.

Koll has spent the last two years improving prevention of C. diff in his hospitals, revamping protocols ranging from housekeeping techniques to quicker diagnosis.

"The minute somebody has diarrhea, you think 'C. diff'," he said.
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Some changes have been obvious, Koll said. A switch from reusable rectal thermometers quickly contributed to C. diff rates that have fallen by 25 percent.

Key to a new collaboration with three dozen Northeast hospitals is a checklist of infection control steps and a “C. diff bundle,” a portable, prepacked kit of supplies that keeps health care workers from having to search for gowns, masks and necessary tools.

“People will do the right thing,” said Koll. “No one wants to give their patients an infection.”

Avoiding C. diff

Best advice is prevention

— Wash your hands frequently with soap and water; alcohol sanitizers don't kill the C. diff bugs. Make sure to wash up before meals, after using the bathroom and after touching potentially contaminated surfaces.
— Ask visitors and health care workers to wash up, too.
— Inquire about hospital cleaning methods. Do they clean twice daily and after fecal accidents? If C. diff is suspected, do they use chlorine-based cleaners?
— If you have diarrhea, ask about a private room. A private toilet is ideal.
— Make sure visitors and staff wear gowns and gloves when they enter the room.
— Consider bringing a 1-to-10 solution of chlorine bleach to clean bedrails, call buttons, door knobs and other potentially contaminated sites.
— Insist on daily bathing and fresh clothing.
— Avoid use of antibiotics unless absolutely necessary.

It's long past time hospitals began to pay attention to their infection control practices related to C. diff, MRSA and other organisms, said Lisa McGiffert, director of the Stop Hospital Infections project for Consumers Union, a patient advocacy group.

Hospital-associated infections affect nearly 2 million patients and are associated with nearly 100,000 deaths each year, according to the CDC.

“Here’s the problem with these bad bugs: They’re very hard to stop when they get inside the body,” McGiffert said. “The only defense we have is prevention.”

Medicare may not pay for C. diff infections

It may take proactive efforts like those proposed by Koll and others to implement hospital-wide control practices. Or it may take punitive efforts, such as the move by federal Medicare officials to cut payments to hospitals for certain avoidable conditions acquired after admission. Last month, Medicare proposed adding C. diff to the growing list of preventable problems after the agency recorded 96,000 cases of the infection in 2007 at an average cost of $59,000 apiece.

In the meantime, patients need to take care into their own hands, often literally, advocates said.

They need to become acutely aware of hand hygiene, making sure to wash their own hands frequently and remembering to ask visitors and health care workers to wash up as well, said Betsy McCaughey, who heads the advocacy group Committee to Reduce Infection Deaths, or RID.

“No matter how dirty the hospital is, if that spore does not go in your mouth, you won’t get C. diff,” she said.

Some patients and their family members have become even more vigilant, bringing their own bleach-infused hand wipes to wash down hospital door knobs and bed-rails, said McGiffert.

“People are cleaning the bathrooms themselves because they’re filthy,” she said. “People have lost faith that the hospitals are going to do those things. They’re taking it on themselves.”

Officials with the CDC and APIC decline to recommend such forceful interventions because clinical studies haven't proven their effectiveness.

But even Donskey, the Ohio scientist, said his research has given him personal pause.

"I might bring along a bottle of bleach to disinfect my room and ask every health care worker who examines me to wash their hands, but I don't think most patients are willing to do that," he said.

Anxiety lingers, three years later

Nearly three years after her last bout with C. diff, Amy Warren said she does everything she can to avoid sources of the infection, including hospitals and antibiotics. She’s acutely aware that it took three doses of vancomycin, the strongest antibiotic available, to get rid of the bacteria after six months.

“If I get sick, I get a panic attack,” she said. "What if the vancomycin doesn't work? I have no other medicine."

She tries to warn friends and family about the dangers of C. diff, urging them to limit their use of antibiotics and to be vigilant about hand hygiene. But, she said, it's clear they're not listening.

"They think, 'How can diarrhea be that bad?'" Warren said. "But this is more than diarrhea."

© 2008 MSNBC Interactive

http://www.msnbc.msn.com/id/24407803/

Title amended: species is always written in lower-case.
-AV

[Dartzap]

Ah yes, C.diff. The NHS has been worried about this for quite a while now. It's managed to get the MRSA rates down, but the C.diff is a right bugger to eradicate.

[PainRack]

Aw shit...................

Does anyone here knows how fucking difficult it is to get immobile patients to wash their hands with soap and water?

[Knife]

Aw shit...................

Does anyone here knows how fucking difficult it is to get immobile patients to wash their hands with soap and water?

Worse than that, you know how hard it is to get mobile and confused patients to wash their hands so not to spread it. The article is a bit 'fearmonger-ish' but it is a problem.

Since C diff is normal flora, I wonder what the chick in the article did to tire out her immune system to get an active case of it?

[PainRack]

Aw shit...................

Does anyone here knows how fucking difficult it is to get immobile patients to wash their hands with soap and water?

Worse than that, you know how hard it is to get mobile and confused patients to wash their hands so not to spread it. The article is a bit 'fearmonger-ish' but it is a problem.

Since C diff is normal flora, I wonder what the chick in the article did to tire out her immune system to get an active case of it?

It says she just gave birth, so that's probably the reason.