I'll start with one of mine:
Insect world domination
Choose from a variety of pests and bugs to lead into insectoid ascendancy over other insects and eventually even humans! Devote R&D time to find new infantry tactics against slipper-wielding killers and develop immunity against the many types of insecticides out there. Fight other species of insects, or negotiate and trade with them. Each species has its own strengths, weaknesses and quirks, of course.
I know SimAnt has been done before, but I am talking about WORLD DOMINATION

